Dr. Ruka Canada
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assess the strategies to be undertaken by professionals in their fields of expertise (veterinary, human
medicine, biology, etc.) in organ/tissue/stem cells transplantation/regeneration, oncology, and genome
for the public health - the benefit of humans and animals
Dr. Ruka
                                 Professional Synopsis Profile

Total Number of Words Published (TWP): 2,347

                                                Miroslaw P. Ruka, D.V.M., Ph.D.
                                                                                        Professor Veterinary Surgery
                                   The Cambridge Center For Medical & Veterinary Sciences Inc.
                                                         55 Yarmouth Street, Suite 204, Guelph, Ontario, Canada N1H 7R4
Telephone / Fax: (519) 763-9192                                               http://www.CCMVS.com                                               e-mail:mp.ruka@ccmvs.com

Dr. Ruka is licensed as a Veterinary Clinical Small Animal Organ Transplant Surgeon by the College of Veterinarians of Ontario (CVO,
license no. 4796) in Ontario, Canada. Dr. Ruka possess an extensive clinical, teaching, research, surgical (including microsurgery and
reconstructive surgery) with diagnostic training from Poland, Holland, Kuwait and Canada in the area of small animals (dog, cat, swine,
monkey, rabbit, rat, and mouse) surgery (liver, lung, heart, spleen, skin, etc.) and vascular surgery involving kidney, liver, pancreas, ileum,
lymph node auto-, allo-, xeno- transplantation, using various immunosuppressive protocols to prolong xeno-graft or allo-graft functional
survival.
In Poland, Warsaw, (1973-1984), after graduation with a D.V.M. degree from the Warsaw Veterinary School and licensed as a General
Veterinary Practitioner, he has joined a Polish Academy of Sciences, its Department of Experimental Surgery and Transplantation (Dr. W.L.
Olszewski, Professor of Surgery & Organ Transplantation and Chairman) at the Medical Research Centre, Faculty of Medicine where he
had worked and received his Ph.D. degree in the field of organ auto- and allo-transplantation and been appointed to an Associate Professor
position. Additionally, he has been involved in a xeno-transplant project involving a rabbit-to-dog liver transplantation model and identifying
that natural antibodies interacting with endothelial cells of the xeno-graft were responsible for the graft hyper-acute rejection.
Dr. Ruka has also been involved in programs of organ transplantation into human recipients in Poland with Dr. W.A. Rowinski’s
(Professor of General Surgery and Organ Transplantation, Institute of Transplantation, Medical School in Warsaw, Poland, who received
Medal of Recognition at the International Transplant Society Meeting held in Rome, 2001) Transplant Team and in Kuwait, Kuwait City
with Dr. George M. Abouna’s Transplant Team (Professor of Surgery & Organ Transplantation, and Chairperson at the Department of
Organ Transplantation, Faculty of Medicine, University of Kuwait, Kuwait), where as an Assistant Professor participated as a Second
Assistant in the surgeries to obtain kidneys from the living related or cadaver donors, kidney procurement and storage, and during their
transplantation into human recipients.
Dr. Ruka's Ph.D. thesis entitled "Impact of Hyperosmolar and Hyperoncotic Solutions on Tissue Water Distribution in Organs to be
Transplanted"was involving surgeries including kidney transplantation; donor/recipient care prior to surgery during and post-surgery;
patients pre-medication and surgical anesthesia; biochemical, immunological, physiological and histological (biopsy) monitoring of donors
and recipients; crystalloid and colloid fluids therapy; diuretic therapy (mannitol, furosemide); angiography; urography and lymphography.
In Holland, Groningen, (1984-1986, Dr. Ch.R.M. Vildevuur, Professor of Surgery and Chairperson, Department of Surgery, Faculty of
Medicine, University of Groningen. Groningen, and Dr. Hans A. Dikken, Director, Central Animal Laboratory, University of Groningen,
Groningen, Holland) Dr. Ruka has been awarded with a Post-Doctoral Fellowship in the field of organ reconstruction. He has investigated
the mechanisms involved in interaction of tissues and body fluids with the permeability, diffusion, electrical, optical and mechanical
properties of implanted artificial (biodegradable) materials such as a poly-ether-urethane (PEU) or (non-biodegradable) carbon fiber and their
use in a reconstruction of the trachea and oesophagus, respectively.
After receiving his Veterinary Dutch Licence to practice a veterinary medicine in its entirety, Dr. Ruka has been practicing in Groningen at
the Small Animal Hospital (Dr. M.A. Van Messel and Dr. J. D. Th. Straatman). During a routine work at this hospital, he gained Western-
European training/experience in a small animal medicine and surgery (dog/cats), including: (1) Soft tissue surgeries (e.g. ovariohisterectomy,
testectomy, mastectomy, penile amputation, patellar reposition, hip displasia, subcutaneous/pinna haematoma, tail amputation, extirpation
of anal glands, lumpectomies); (2) Radiology of hips, long bone fractures, abdomen and thorax; (3) Dental surgery and dental preventive
medicine; (4) Anesthesia - sedation with thiopental, maintaining a surgical anesthesia with isoflurane or halotan, and pre-/ post-operative
animal care; (5) Treatment of diseases - e.g. skin allergies due to external / internal parasites, food or bathing shampoos, Vit. D deficiency,
prevention of heat and pregnancy in bitches, false pregnancy, parvovirus infection, diabetes, kidney / liver diseases, etc.; (6) Vaccination of
dogs for hepatitis, Adeno Type 2, Parainfluenza, Leptospirosis, Parvovirus, Rabies, and vaccination of cats with Felocell, Felocell RC,
Felocell CVR, Fe IV, and Rabies.
In Kuwait, Kuwait City, (1986-1989, Dr. George M. Abouna, Professor of Surgery & Organ Transplantation, and Chairperson at the
Department of Organ Transplantation, Faculty of Medicine, University of Kuwait, Kuwait) as an Assistant Professor, Dr. Ruka has been
investigating an influence of various aspects of organ procurement / storage on pre-/ and post-transplant organ viability. This involved the
pancreas (monkey and rats), liver (dog-to-dog), or Islets of Langerhance (monkeys, pigs, rats) preservation and allo-transplantation. He had
also been, as stated above, involved in clinical program of organ transplantation into human recipients.
In Canada, Guelph, Ontario, (1990-to present) he is involved in comparative independent as well as collaborative clinical, teaching,
research and diagnostic work / programs in the area of surgeries, anesthesiology, organ procurement / storage / transplantation (pancreas,
kidney, liver), and mechanisms of organ allo-/ xeno-/ rejection in various animal species (dogs, cats, pigs, rats).
At the University of Guelph, (1990-2000; Dr. D.G. Butler, Professor of Veterinary Medicine and Chairperson, Department of Clinical
Studies, OVC - Ontario Veterinary College, University of Guelph, Guelph, Ontario) Dr. Ruka has been awarded with a Post-Doctoral
Fellowship in the field of organ transplantation, as a continuation of his previous work / experience / knowledge gained during academic
appointments in Poland, Holland and Kuwait. He has established an independent research in the field of organ preservation and using
experimental models of the rat / dog pancreas and dog / pig kidney to carried out an evaluation: (a) of commonly used organ preservation
solutions (Ringer's Lactate Solution, Euro-Collins, Belzer UW CSS) on abrogation of tissue edema and suppression of tissue autolysis
following 96 hours of cold storage (including preservation solution's pH, osmolarity, oncotic pressure, -COOH group, free
radical scavengers, low / high molecular weight of selected ingredients, perfusion pressure on organs harvested from fasted vs. non-fasted
donors, etc.); and (b) an evaluation of post-flushing and post-ischemic tissue injuries following 2 hours and 96 hours of pig and dog kidneys
cold storage using (31P)-MRS and (1H)-MRI techniques.
Furthermore, in 1991 Dr. Ruka has introduced to the University of Guelph xeno-transplant programs (a pig - universal organ donor; The 1st
International Congress On Xenotransplantation, Minneapolis, Minnesota) triggering an establishment of the University of Guelph
Xenotransplant Group [Clinical and Investigative Medicine 1993; 16(4) B140-865], and at the Veterinary College in Guelph (Ontario,
Canada) a Comparative and Clinical Veterinary Transplantation Group.
During this period of his work at the University of Guelph, Dr. Ruka has developed and participated in several projects with the
Departments of VMI, Pathology, Population Medicine, Clinical Studies, MRI Facility, Reproductive Toxicology (Health Canada, Ottawa),
Novartis (gnotobiotic surgeries), etc.
At the Centre of Clinical And Comparative Medicine Inc. (CCCM, 1997-1998; Mr. Ronald W.P. Struthers, President and C.E.O.) in
Guelph, Ontario, Dr. Ruka has been appointed as a Professor of Companion Small Animal Transplant Surgery and Experimental Surgery,  
and been responsible for developing, co-ordinating and implementing all research and teaching programs in the field of small animal clinical
and comparative transplant surgery / medicine within the CCCM and with other Universities, Hospitals or Medical Centres.
Currently, at The Cambridge Center for Medical & Veterinary Sciences Inc. (CMVS, 1998-present, Guelph, Ontario) Dr. M.P. Ruka,
as a Founder and Owner and the First Director of the Company has been appointed as a Professor Veterinary Surgery and the Chairperson
of the Board of Directors (additionally to the other senior executive positions held), and is involved in all of the clinical, teaching, research
and diagnostic programs in the field of small animal (dogs and cats) medicine, small animal surgery, and small animal organ and tissue
transplantation (in comparative studies with a human being) which are implemented and planned to be expanded by a construction (in GTA)
of 280,000-square foot facility, a 7-level building (that includes 4 underground levels and 3 levels above the ground, to be built in accordance
with the human hospital's standards and specifications) named (provisional name) here as a Hospital (teaching-learning General Hospital) in
a PHASE ONE and PHASE 2. For more information, please refer to the company's web page: http://www.ccmvs.com  
At the Guelph Animal Hospital (GAH, 2003-2010, Dr. Robert Butler, Director and Owner of Guelph Small Animal Hospital, for dogs
and cats only) in Guelph, Ontario, participated in numerous procedures with Dr. Butler's and Dr. Joseph Rouseau's clinical surgeries such
as: ovariohisterectomy(s), testectomy(s), skin tumors removal (including papillomas), skin parasites removal, tail amputations, leg
amputation, toes(s) amputation in dogs, declaw in cats, skin transplant (non-vascularised free flap), dental procedures, etc. Furthermore, he
had been familiarized with GAH's (1) departments/units (e.g. Surgical Room, Dental Area, Consulting Rooms, Grooming Center, Nutritional
Area, Holding / Condos Area, Administration Office, Reception Desk Area, Doctors' Offices, Computerized Patients' Filing System); (2)
with the nurses and staff responsibilities; (3) with the techniques of using digital (general and dental) X-Ray equipment; (4) with the
techniques of blood, other body fluids, and tissue biopsies collection; (5) with the protocols of sedation (e.g. B.A.G. or Turbogesic) prior to
induction of surgical anesthesia (e.g. Thiopental) for the animal's intra-tracheal intubation and maintaining a general surgical anesthesia with a
gas mixture of Isoflurane / Oxygen; (6) with the protocols of patients pre-, during, and post-surgical care / pain management, etc.; and (7)
with a clinical application of alternative medicine use / treatment (homeopathy, naturopathy, holistic medicine, acupuncture, herbal
medicine).
Dr. Ruka in 2003-2004 has introduced to Dr. Robert Butler and his staff a new surgical technique named here as an intra-dermal
technique of suturing using atraumatic absorbable (biodegradable) sutures for closing a subcutaneous tissue and the skin layers during
laparotomies in dogs and cats, which in its modification is used in the GAH, and the Guelph area as well. This technique is not requiring any
further intervention in a suture removal after 7-10 days post-surgery, in contrary to the traditional use of non-absorbable suture materials.
In 2004-2005, for the Laser Surgical Unit used in surgeries at the GAH, Dr. Ruka has designed, constructed and successfully tested in a pre-
clinical (in-vitro) setting and in clinical surgical patients (by Dr. Butler and Dr. I. Smolkin) a new model of Attachable Smoke Removal Valve
(Prototype 2), to e.g. (1) maintain sterile condition of surgical procedures, (2) simplify the surgical procedures, (3) increase the safety of
individuals involved in surgeries, and (4) to reduce the cost of surgeries.
Furthermore, Dr. Ruka has provided and shared with Dr. Robert Butler (Director, GAH) his:
(1)   surgical technique of halting tissue bleeding from e.g. muscles or sub-cutaneous tissues;
(2)   diagnostic analysis, during surgical procedures, of the patient tongue's color, temperature, pre-/ capillary and micro-/ capillary
    color / fulfilment / pulsation as a reflection of the patient's micro-/ capillary blood flow through the internal (abdominal) organs
    e.g. GIT, liver, kidney, pancreas and their (tissue) oxyganation;
(3)   use of the Full Blood Laser Cellular Analyser for e.g. liver, pancreas, kidney, bone-marrow screening as an important diagnostic
    tool in evaluation of the patient's health status, additionally to the physical examination, urine analysis, fecal analysis, X-ray,
    ultrasound, etc.;
(4)   recording the used doses of pills / tablets or any other medication(s) in the form of solutions / fluids in mg / kg or g / kg of the
     patient's body weight in the patients’ computerised medical records;
(5)   use of DOMITOR in sedation protocol(s) and its negative effect on the patient's cardiovascular system (e.g. blood flow and blood
     oxygenation) - publication in preparation;
(6)   collecting data of numerous measurements during surgery (e.g. blood pressure, body temperature) and presenting them as a
     MEDIAN (X) but not as an AVERAGE. Presenting such clinical data in the form of MEDIAN (X) or MEAN (X) is allowing us
     to calculate SD (Standard Deviation).
(7)   use of a proper medical terminology e.g. ovariohisterectomy, testectomy in a clinical setting.
The International Clinical & Comparative Medical & Veterinary Sciences Journal (ICCMVS Journal, 2010 - present, Dr. M.P.
Ruka -Publisher) is an on-line open scientific Journal which has been established by Dr. Ruka for the purpose of introducing an-instant-
publishing system (in less than 24 hours) to the professional colleagues around the World, the authors' of manuscripts presenting their
various clinical, teaching, applied (clinical) research ideas, new concepts, techniques, point of views and / or novel methods of treatment
which are published without any delay(s), and for the purpose of securing and preserving the authors' intellectual rights, as well. For more
information, how to submit manuscript, please refer to the Journal's web page: http://www.ccmvsjournal.com
As a result of his work and collaborations 83 papers have been presented on several Transplantation Society of Canada, Canadian Society of
Nephrology, Xenotransplantation, Microscopical Society of Canada, Royal College of Physicians and Surgeons of Canada, etc. meeting in
the form of poster / oral presentations, and published as regular articles , proceedings or abstracts in refereed journals.
During this period of time, additionally, he attended 30 national / international meetings / conferences, and became member of the Canadian
Transplantation Society, The American Society of Transplant Surgeon, Xenotransplantation Society, and The College of Veterinarians of
Ontario.
Furthermore, on several occasions, as an invited guest-speaker Dr. Ruka has given lectures / seminars at the Harvard University, Boston,
MA; Laval University, Quebec City, Quebec; University of Guelph, Guelph, Ontario; and Washington University Center, Washington DC,
on the subject of surgery, organ transplantation and transplant related immunology.
During his career Dr. Ruka has performed more than 3,000 surgical operations, using 46 different surgical models / techniques, including
more than 250 kidneys auto-/ allo-transplantation in dogs; 4 kidneys pig-to-dog xeno-transplantation; 3 kidneys pig-to-pig auto-  
transplantation; 40 livers allo-transplantation in dogs and pigs; 124 livers rabbit-to-dog xeno-transplantation. The results of his surgical,
research and teaching activity(s) have been published (83 publications).
For more details about Dr. Ruka's work and the development of his career over the years please, refer to his Curriculum Vitae,
enclosed.                

            
            
            
                                                                                                                                                      Encl. Dr. Ruka's Curriculum Vitae
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