| Dr. Ruka Canada |
The CMVS is a clinical, teaching, research with diagnostic labs and services CENTER established to
assess the strategies to be undertaken by professionals in their fields of expertise (veterinary, human
medicine, biology, etc.) in organ/tissue/stem cells transplantation/regeneration, oncology, and genome
for the public health - the benefit of humans and animals
assess the strategies to be undertaken by professionals in their fields of expertise (veterinary, human
medicine, biology, etc.) in organ/tissue/stem cells transplantation/regeneration, oncology, and genome
for the public health - the benefit of humans and animals
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Curriculum Vitae MIROSLAW P. RUKA D.V.M., Ph.D. Total Number of Words Published (TWP): 8,906 Address for correspondence: Dr. Miroslaw P. Ruka Professor Veterinary Surgery THE CAMBRIDGE CENTER FOR MEDICAL & VETERINARY SCIENCES INC. 55 Yarmouth Street, Suite 204, Guelph, Ontario, N1H 7R4 Canada http://www.CCMVS.com Telephone / Fax : (519) 763-9192 E-mail: mp.ruka@ccmvs.com PERSONAL: Place of Birth: Warsaw, Poland Citizenship: Canadian Country of residence: Canada (since July 1989 – present) Address of permanent 204-55 Yarmouth Street residence: Guelph, Ontario N1H 7R4, Canada Tel.: / Fax: (519) 763-9192 Present address of THE CAMBRIDGE CENTER FOR MEDICAL & VETERINARY SCIENCES INC. employment: 55 Yarmouth Street, Suite 204, Guelph, Ontario N1H 7R4, Canada Telephone: / Fax: (519) 763-9192 http://www.CCMVS.com E-mail: mp.ruka@ccmvs.com EDUCATION: 1964-68 -High School; J. Slowacki - Lyceum No. 7, Warsaw, Poland 1968-74 -Warsaw Veterinary School, Faculty of Veterinary Medicine, Academy of Agriculture, Warsaw, Poland 1974 -Degree: Doctor of Veterinary Medicine (D.V.M.) obtained from the Warsaw Veterinary School, Faculty of Veterinary Medicine, University of Agriculture and Ministry of Agriculture in Warsaw, Poland, to practice a veterinary medicine as a General Veterinary Practitioner in its entirety. 1975-80 -Degree: Doctor of Natural Science (Ph.D.) in Experimental Medicine obtained from the Polish Academy of Sciences, Faculty of Medicine, Medical Research Centre, Warsaw, Poland Title of Ph.D. Thesis: "Impact of Hyperosmolar and Hyperoncotic Solutions on Water Distribution in Organs to be Transplanted". VETERINARY LICENSES: 1974 Polish Licence: to practice as a Doctor of Veterinary Medicine (D.V.M.) in the field of veterinary medicine in its entirety. 1985 Dutch license: to practice as a Doctor of Veterinary Medicine (D.V.M.), signed by Her Majesty Beatrix, Queen of The Netherlands, etc., etc., obtained with admission to the Practice of Veterinary Medicine in its entirety from the Faculty of Veterinary Medicine, University of Utrecht, and Ministry of Agriculture and Fisheries in The Hague, Holland. 1995 Canadian license: obtained with admission to the Veterinary Medicine Practice as a Veterinary Small Animal Organ Transplant Surgeon (Restricted), issued by the Registration Committee of the College of Veterinarians of Ontario (CVO) - license no. 4796. MAJOR FIELDS OF SPECIALIZATION: Clinical and comparative medical and veterinary small animal organ/tissue transplantation / physiology and immunology SPECIAL FIELDS OF SPECIALIZATION FOR Ph.D.: Small animal soft tissue surgery, organ transplantation, organ preservation, organ procurement, and transplantation related immunology LANGUAGES: English; Polish PRESENT POSITION(S) held at: • The Cambridge Center For Medical & Veterinary Sciences Inc.(CCMVS): Faculty Member: - Professor Veterinary Surgery Senior Executive Positions: - Chairperson - 1st Director - President and Secretary - Voting Member of the Board of Directors, - Founder & Owner • International Clinical & Comparative Medical & Veterinary Sciences Journal (ICCMVS): - Publisher - Founder & Owner THE HISTORY OF EMPLOYMENT: * DEPARTMENT OF EXPERIMENTAL SURGERY & TRANSPLANTATION, Medical Research Centre, Polish Academy of Sciences, Faculty of Medicine, Warsaw, Poland Dr. W.A. Rowinski - Professor of Transplant Surgery Dr. W.L. Olszewski - Professor of Transplant Surgery & Chairperson -From May 1975 to December 1984; Scientific Positions (in transplant/experimental surgery): - 1975-1980 - Assistant; 1980-1984 - Adjunct=Associate Professor of Experimental (Transplant) Surgery * DEPARTMENT OF EXPERIMENTAL SURGERY, Faculty of Medicine, University of Groningen, Groningen, Holland (Dr. Ch.R.M. Wildevuur - Professor of Surgery & Chairperson;) -From January 1984 to January 31, 1985; Scientific Position: Post-Doctoral Fellowship * CENTRAL ANIMAL LABORATORY, Faculty of Medicine, University of Groningen, Groningen, Holland; (Dr. H. Dikken - Director of the C.A.L); -From January 1984 to January 31, 1985; Scientific Position: Post-Doctoral Fellowship * THE VETERINARY SMALL ANIMAL CLINIC; M.A. van Messel and J.D.Th. Straatman, Groningen, Holland -From August 1985 to August 31, 1986; Position: Veterinary Small Animal Surgeon (Surgery) * DEPARTMENT OF ORGAN TRANSPLANTATION, Faculty of Medicine, Kuwait University, Kuwait (Dr. G.M. Abouna - Professor of Transplant Surgery and Chairperson) -From August, 1986 to August 31, 1989; Scientific Position: Assistant Professor of Experimental (Transplant) Surgery. * DEPARTMENT OF CLINICAL STUDIES, Faculty of Veterinary Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada (Dr. D.G. Butler - Professor of Medicine and Chairperson); -From June 1990 to June 18, 1991; Scientific position: Post-Doctoral Fellowship (in Transplant Surgery) -From June 19, 1991 to June 1997. Scientific position: Associate Research Scientist in Experimental (Transplant) Surgery * THE CENTRE OF CLINICAL & COMPARATIVE MEDICINE INC. (CCCM), Guelph, ON, Canada; (Mr. Ronald W.P. Struthers - C.E.O. & President) Positions held-from June 1997 to November 6, 1998: 06-1997 to 1998 Professor of Clinical Small Animal Transplant Surgery & Experimental Surgery 06-1997 to 1998 Director, Clinical Small Animal Organ Transplant Programs & Services 06-1997 to 1998 Director, Xenotransplant Programs & Services to Nov. 1998 Vice-President for Research and Senior Chief Scientific Officer * THE CAMBRIDGE CENTER FOR MEDICAL & VETERINARY SCIENCES INC. (CCMVS); Guelph, ON, Canada (http://www.CCMVS.com); Dr. M.P. Ruka, Founder & Owner; Position(s) held from November 26, 1998 to present: Professor Veterinary Surgery; 1st Director; Chairperson of the Board of Directors; Voting Member of the Board of Directors; President and Secretary; Founder & Owner * THE GUELPH ANIMAL HOSPITAL (GAH, Guelph, Ontario, Canada) Dr. Robert Butler - Director and Owner Position(s) held: Veterinary Small Animals Soft Tissue Surgeon (Surgery) From January 15, 2003 to November 01, 2010 * CLINICAL & COMPARATIVE MEDICAL & VETERINARY SCIENCES JOURNAL (ICCMVS), Guelph, Ontario, Canada (www.CCMVSJOURNAL.com); Dr. M.P. Ruka, Founder & Owner; Position(s) held from July 10, 2007 to present: Publisher; Founder & Owner MAJOR FIELDS OF CLINICAL, APPLIED AND BASIC RESEARCH INTERESTS: (1.) CLINICAL ORGAN TRANSPLANTATION: kidney and pancreas allograft transplantation into uremic or/and diabetic patients (dogs and cats), particularly: - selection of the donor and donor-recipient matching system - donor pre-treatment, "untouched" organ harvesting technique and cold storage for transplantation - selection of flushing/preservation solution for temporally cold (4°C) storage - recipient pre-treatment prior to organ transplantation - treatment of post-reperfusion injury - recipient post-operative management - induction of the modern immunosuppressive protocol to prevent acute or chronic rejection of transplanted organ and to achieve its permanent accommodation (transplantation tolerance) - selection of antibiotic therapy - short- and long-term evaluation of graft(s) functional survival post-transplantation (2.) EXPERIMENTAL SOLID ORGANS / TISSUES PRESERVATION & TRANSPLANTATION (liver, kidney, pancreas, islet cells, heart, lungs, ileum) in animals, such as dogs, pigs, rabbits, rats, particularly: - suppression of the harmful effect of warm and cold ischemia on stored organs prepared for transplantation (e.g. dehydration phenomenon, and/or Ca++ channel blockers). - mechanism of tissue fluid formation and its transport through the capillary wall and across the interstitial space in ischemic tissue(s). - post-transplantation flushing/ischemic reperfusion injury and tissue inflammatory response in organs exposed to short and long-term warm/cold ischemia (eg. generation of free radicals, IL-1; IL-6 and other cytokines; TNF; adhesion molecules; ß-thromboglobulin), and their effects on acute and/or chronic tissue rejection in auto-, allo- and xeno-graft models of kidney transplantation. (3.) XENOGENIC TRANSPLANTATION OF SOLID ORGANS & TISSUES IN DISCORDANT ANIMALS: The mechanism of hyperacute/acute - vascular/tissue rejection in immediately or cold (4°C) stored vascularized kidney xenograft transplanted from: - unmodified pig-donor to modified (any)-recipient by: immunosuppression (CsA, brequinar sodium, etc.), plasmapheresis, donor bone marrow, total body irradiation, splenectomy, etc. - modified pig-donor to modified (any)-recipient: e.g. production of transgenic/chimeric pig/(recipient) - modified pig-donor to unmodified (any)-recipient, particularly: to overcome the problem of hyper/acute and/or accelerated vascular/tissue rejection and to achieve a permanent accommodation of the xenograft. (4.) ORGAN RECONSTRUCTION: Functional reconstruction of the bile duct, oesophagus, trachea, urinary bladder, cornea (intracorneal lenses) and continuity of the vascular system using animals such as dogs, rabbits and rats, particularly: - mechanism of biomaterial interaction (e.g. PEU, PLL, PU, carbon fiber) with the tissues/fluids of the body, and effects of the tissue reactivity on changes in permeability, electrical, optical and mechanical properties of the novel artificial materials used for reconstruction. (5.) ETHICAL ISSUES OF USING ANIMALS for: a.) Medical clinical, applied, and/or basic research; b.) Teaching in medical, veterinary and other biologically oriented schools/universities; c.) In a clinical veterinary setting and its application for human and animals benefit; d.) Education of the new generation of physician/veterinarian scientists/researchers and/or biologists in medical and/or veterinary and other related disciplines. PROFESSIONAL EXPERIENCE: (1.) GENERAL CLINICAL VETERINARY PRACTICE: In Poland (Warsaw), in Holland, at M.A. van Messel and J.D.Th. Straatman’s Small Animal Hospital in Groningen, and in Canada, Guelph, Ontario (at Dr. Robert Butler’s Guelph Animal Hospital), in the veterinary clinical small animal practice (mainly dogs and cats), including: a) Surgery, such as ovariectomy, ovariohysterectomy, testectomy, prostatectomy, mastectomy, penile amputation, enterectomy, subcutaneous or pinna hematoma, gastric torsion, bone fracture, patellar reposition, hip dysplasia, extirpation of anal glands, lumpectomies, etc.; b) Radiology of hips, long bone fractures, abdomen and thorax cavities using digital radiography ; c) Dental surgeries and dental preventive medicine; d) Anesthesia: (1) sedation with e.g. meperidine or ketamine, acepromazine, atropine; (2) induction with e.g. thiopental, (3) surgical anesthesia with isoflurane/halothane and oxygen and (4) pre-/post-operative animal care; e) Treatment of diseases such as skin allergies due to external/internal parasites or food, otitis external, endometritis, Vit. D deficiency, prevention of heat and pregnancy in bitches, false pregnancy, parvovirus infections, diabetes, kidney and liver diseases, etc.; f) Vaccination of dogs for hepatitis, adeno type 2, parainfluenza, leptospirosis, parvovirus, rabies and cats with felocell, felocine, felocell RC, felocell CVR, FelV, rabies. (2.) ORGAN TRANSPLANTATION in CLINICAL and COMPARATIVE MEDICINE: In Poland (Polish Academy of Sciences, Warsaw), in Kuwait (University of Kuwait, Kuwait City) and in Canada (University of Guelph, Ontario Veterinary College and currently at The Cambridge Center for Medical & Veterinary Sciences Inc., in Guelph, Ontario): (a) participating in Human Organ Transplant Program(s) as a second assistant in the surgeries to obtain kidneys from living related donors or from cadaver donors, kidney procurement and storage, and during their transplantation into human recipients; (b) research and surgery (including microsurgery) training in the area of small animals (dog, swine, monkey, rabbit, rat, and mouse) soft tissue surgery (liver, lung, heart, spleen, skin) and vascular surgery involving kidney, liver, pancreas, ileum, lymph node auto-, allo-, xeno-transplantation, using various immunosuppressive protocols to prolong xenograft and/or allograft functional survival (including more than 250 kidney auto/allo-transplantation in dogs); (c) performing lymphography, angiography, urography, inulin renal function test, and the measurement of changes in total tissue water concentration in various organs. (d) microsurgery - collecting of the rat pancreas for preservation and transplantation using operating microscope (see Appendix II). (e) investigating the influence of various aspects of organ procurement on pre- and post-transplant organ viability, involving pancreas (monkey and rats), liver (dog-to-dog) or islet of Langerhans ( monkeys, pigs and rats) allo -transplantation. (f) evaluating of commonly used organ preservation solutions on abrogation of tissue edema and suppression of tissue autolysis following 96 hrs cold storage of rat/dog/pig pancreas/kidney (including solution's pH, osmolarity, oncotic pressure, -COOH group, free radical scavengers, and low/high molecular weight of selected ingredients of cold storage solutions, perfusion pressure, donor fasted vs. non-fasted, etc.); (g) reassessing the effect of kidney collection, storage and transplantation on organ function post-transplantation using a pig auto-transplantation protocol following UNOS standards; (h) reassessing pig kidney hyper-acute rejection following transplantation into the laboratory beagle dog with and without natural anti-pig antibody depletion by extracorporeal circulation of the recipient's blood through the donor pig's liver; (i) successfully creating, in utero, a 50% pig/dog chimera (assessed by DNA flow cytometric analysis based on DNA content) by the injection of dog bone marrow cells into the abdomen of the fetal pigs; (e) development of surgically -induced endometriosis in a mouse model, etc.; (j) currently establishing, implementing and promoting at The Cambridge Center for Medical & Veterinary Sciences Inc. (CMVS) clinical, teaching, research and diagnostic programs in the field of small animal (dogs and cats) medicine, small animal surgery, and small animal organ and tissue transplantation (in comparative studies with a human being) which planned to be expanded by a construction (in GTA) of 280,000-square-foot facility, a 7-level building (that includes 4 underground levels and 3 levels above the ground, to be build in accordance with the human hospital's standards and specifications) named here as a Hospital (teaching- learning General Hospital) in a number of stages and sub-stages. For more information, please refer to the company's Phase One and Phase 2 of this project. (3.) TEACHING: - Supervising and teaching senior, junior and technical staff the scientific methodology used in biological experiments, surgical and microsurgical techniques on animals, and animal care before and after operation, in agreement with Canadian Council on Animal Care (guide to the Care and Use of Experimental Animal, Vol. 1 & 2) and Animals for Research Act, Ontario, 1983; - Seminars / lectures for 4th year students and senior/junior technical staff on the subject of organ transplantation and transplantation related immunology - "Elective in Veterinary Clinical Immunology" course (Canada); - Seminars/lectures for under-graduate students on the subject of surgery (type of incisions, anatomy of abdominal wall, wound healing, tissue trauma/ischemia, surgical infections, shock, trauma, metabolism and the role of endocrine and immune systems in surgery, hemeostasis, etc.) including pre-operative preparation and post-operative management of surgical patients (Canada). - Preparation of under-graduate and graduate students for their oral presentations or written assignments on subjects related to organ transplantation and/or general surgery (Canada). (4.) SEMINARS / LECTURERS given for UNDER/GRADUATE and POST-GRADUATE courses: - Human Living Organ Donors - Source of the Perfect Organ: The Risk; - Transplantation Tolerance; - Transplantation and the Religious Believes; - Diagnosis of Rejection vs. Infection and Drug Toxicity; - Clinical Organ Transplantation in Companion Animals; - Treatment of Allo-Graft Rejection; - Diet in Organ Transplant Recipients; - Organ Transplantation (Medical Research) and Animal Rights Activists; - Ethical Issues of Using Animals for Medical Research (5.) ADMINISTRATION: 1. Organizing work at the operation theater and at the small animal (dog) farm. (at the Department of Experimental Surgery and Transplantation, Medical Research Center, Faculty of Medicine, Polish Academy of Sciences, Warsaw, Poland, 1975-1983). 2. Supervising redistribution of incoming and outgoing pharmaceuticals for the small animals such as dogs, pigs, rabbits, monkeys and rats (at the Department of Experimental Surgery and Transplantation, Medical Research Center, Faculty of Medicine, Polish Academy of Sciences, Warsaw, Poland, 1975-1983). 3. Appointed to Associate Professor Position at t the Department of Experimental Surgery and Transplantation, Medical Research Center, Faculty of Medicine, Polish Academy of Sciences, Warsaw, Poland, 1980-1984. 4. Acting Chairman in the absence of the departmental chairman (on a few occasions in Poland and Kuwait). 5. Organizing the departmental research seminars (Poland, Kuwait). 6. Organizing Microsurgical Laboratory at the Ontario Veterinary College (at the Department of Clinical Studies, Ontario Veterinary College, OVC, University of Guelph, Guelph, Ontario, Canada, 1990-1997). 7. Evaluation of surgical procedures on behalf of the Animal Care Committee, University of Guelph, Ontario (Canada, 1995). 8. Writing Manual for the CCCM’s Faculty & Staff Position Interview(s), Guelph, ON (Canada, 1997). 9. Establishing and writing the Guidelines for the CCCM’s Ethics Committee for The Center for Clinical & Comparative Medicine (internal use) Guelph, Ontario (Canada, 1997-1998). 10. Establishing The Cambridge Center for Medical & Veterinary Sciences Inc. – (Dr. M.P. Ruka, Founder & Owner) for the purpose of raising US$16.5 million to build according to the human hospital’s specifications in Greater Toronto Area (GTA) a teaching-learning 300,000-square-feet General Hospital - Small Animal Hospital (name still to be decided in accordance with the College of Veterinarians of Ontario regulations), where the clinical, teaching, research with diagnostic labs and services programs to assess the strategies to be undertaken by professionals in their fields of expertise (veterinary, human medicine, biology, etc.) in organ/tissue/stem cells transplantation/regeneration, oncology, and genome for the public health - the benefit of humans and animals - will be carried out - see PHASE ONE and PHASE 2 (Canada, From November 1998 – to present). 11. Dr. Ruka is Chairperson of the CMVS Board of Directors, First Director, and the President & Secretary at The Cambridge Center for Medical &Veterinary Sciences Inc. (CMVS) (Canada, 1998-to present). 12. Dr Ruka is holding a Faculty position of Professor Veterinary Surgery at The Cambridge Center for Medical & Veterinary Sciences Inc. (CMVS) (Canada, 2007-to present). 13. Writing The CMVS Manual of Organ/Tissue Transplantation for Humans and Animals Benefit – Development, Programs & Regulations (Canada, 1999 - to present). 14. Writing, preparing and completing the Handbook for the CMVS' Programs Investor (Business Plan) and its version for the Canadian Government, as well (with 10 Chapters, Canada 2000-2001). 15. Designing, writing, preparing and up-dating The Cambridge Center for Medical &Veterinary Sciences Inc. (CMVS) web page - http://www.CCMVS.com (Canada, 2004 – to present). 16. Establishing on-line an-open International Clinical & Comparative Medical & Veterinary Sciences Journal – (Dr. M.P. Ruka, Founder & Owner, Publisher) providing an instant publishing system (in less than 24 hours) for the professional colleagues around the World, the authors' of manuscripts presenting their various clinical, teaching, applied research ideas, new concepts, techniques, point of views and/or novel methods of treatment which are published without any delay(s), and for the purpose of securing and preserving the author's intellectual rights, as well. Journal’s web page: http://www.CCMVSJOURMAL.com (Canada, 2007-to present). RESEARCH PROJECTS FUNDED: 1986-1987 The effect of isoosmolar, hyperosmolar and hyperoncotic solutions on rat pancreas stored at 4°C for up to 96 hrs (Principal investigator, grant from the University of Kuwait in the amount of C$4,400.00). 1990-1992 The effect of in vivo flushing and simple cold (4°C) preservation in UW Belzer solution on the wet weight and morphology of the rat/dog pancreas and pig/dog kidney. (Principal investigator, grant from the Department of Clinical Studies, OVC, University of Guelph, Guelph, Ontario, Canada in the amount of C$5,000.00). 1990-1992 The effect of flush-preservation solution with or without free radical inhibitors on the change in the wet weight and morphology of rat pancreas exposed to cold ischemia (4°C) for a period of 96 hours (Principal investigator, grant from the Department of Clinical Studies, OVC, University of Guelph, Guelph, Ontario, Canada in the amount of C$5,000.00). 1991-1993 Use of (31P)-MRS and MRI (1H) to assess pre- and post-transplantation pig and dog kidney viability (Principal investigator, cooperation with Dr. E. Janzen, MRI Facility). 1992-1993 Guyton's sphere in rat treated with CCl4 (cooperation with Dr. E. Janzen, principal investigator). 1993-1995 A pilot project to test the hypothesis that it is feasible to modify the kidney of a pig to make it more acceptable immunologically when transplanted into a dog. (Principal investigator, grant from the Ontario Veterinary College and the Department of Clinical Studies, OVC, University of Guelph, Guelph, Ontario, Canada in the amount of C$13,000.00). 1994-1995 Development of a rodent model for investigations of the pathophysiology of endometrosis: Applications of MRI/MRS in the assessment of endometriotic lesions (cooperation with Dr. E. Janzen, Guelph, Ontario and Dr. W. Foster, Ottawa, Ontario, principal investigators). INVITED as GUST SPEAKER to deliver SEMINARS / COURSES / LECTURES: 1981 - from Dr. N.L. Tilney, Professor of Surgery, Surgical Research Laboratory, Harvard Medical School, Boston, MA (7 days). 1983 - from Prof. Dr. V. Bartos, Department of Experimental Surgery, Czechoslovak Academy of Sciences, Prague, Czechoslovakia (4 weeks). 1986 - from Dr. J. Gajentaan, Professor of Medicine, Department of Small Animal Surgery, Faculty of Veterinary Medicine, University of Utrecht, Holland (3 days). 1987 - from Dr. J. Gajentaan to deliver a lecture at the XXIII World Veterinary Congress (Small Animal Veterinary Association), Montreal, Canada (6 days), entitled: Current problems of the oesophagus reconstruction: clinical and experimental studies. 1990 - from Dr. R. Guidoin, Professor of Surgery, Experimental Surgery Laboratory, Pavillon de Services, Faculty of Medicine, Laval University, Quebec City, January 15th, (1 day), to deliver a lecture entitled: The pancreas preservation: past, present, and future. 1990 - From Dr. D.G. Butler, Professor of Veterinary Medicine, Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Ontario, Canada, February 14, (2 days). 1992 - from Dr. A. Kaushik and Dr. P. Shewen to deliver two lectures for the seminar in the "Elective in Veterinary Clinical Immunology" course at the Ontario Veterinary College, University of Guelph, Guelph, Ontario, on November 2 and 6, 1992, for 4th year students, entitled: 1. The Effect of HLA Tissue Typing, ABO Blood Group Matching and Blood Transfusion on Cadaver (CD), Living Related (LRD) and Living Non-Related Donor (LN-RD) Graft Survival in Recipient With Immunosuppression. 2. Introduction to the Xenograft Transplantation Program at the University of Guelph. 1993 - From Dr. D. Benn, the Central Animal Facility, OVC, University of Guelph, Guelph, Ontario, April 29, 1993, to deliver a seminar entitled: Introduction to organ transplantation for the benefit of human medicine and the benefit of companion animals (dog/cat). 1993 - From Dr. D. Benn, the Central Animal Facility, OVC, University of Guelph, Guelph, Ontario, November 25, 1993, to deliver a seminar entitled: Kidney xenograft transplantation for the benefit of human and veterinary medicine. 1994 - From Drs. A. Kaushik and P. Shewen to deliver a lecture for two seminars in the "Elective in Veterinary Clinical Immunology" course, at the Ontario Veterinary College, University of Guelph, Guelph, Ontario, organized on February 1 and March 8, 1994, for 4th year students, entitled: The effect of MHC Class I and Class II antigens, ABO blood group matching and blood transfusion on cadaver (CD), living related donor (LRD) and living non-related donor (LN-RD) graft survival in recipient with immunosuppression. 1994 - From Dr. David H. Sachs, Professor of Surgery and Director, Transplantation Biology Research Centre, Harvard Medical School, Massachusetts General Hospital, Boston, MA, and Dr. A. Benedict Cosimi, Professor of Surgery Transplantation Unit, Massachusetts General Hospital, Boston, MA, April 22, 1994, to deliver a seminar entitled: Xenotransplantation: Pig kidney to dog. 1994 - From Dr. Jimmy A. Light, Professor of Surgery, Director, Transplantation Services, Washington Hospital Centre, Washington, DC, May 4, 1994, to deliver a seminar entitled: Organ preservation: Factors influencing tissue resistance to cold ischemic injury. 1994 - From Dr. D. Benn, the Central Animal Facility, Ontario Veterinary College, University of Guelph, Guelph, Ontario, October 20, 1994, to deliver a seminar entitled: Mechanism of Tissue Rejection in Allo- and Xeno- Grafts Post Transplantation. 1995 - From Drs. A. Kaushik and P. Shewen to deliver a lecture for two seminars in the "Elective in Veterinary Clinical Immunology" course, at the Ontario Veterinary College, University of Guelph, Guelph, Ontario, organized on February 7 and March 14, 1995, for 4th year students, entitled: The effect of MHC Class I and Class II antigens, ABO blood group matching and blood transfusion on cadaver (CD), living related donor (LRD) and living non-related donor (LN-RD) graft survival in recipient with immunosuppression. 1995 - From Dr. Denna Benn, Director, the Animal Care Services, at the University of Guelph, Guelph, Ontario, October 16, 1995, to deliver lectures at the seminar entitled: Surgical techniques for under-graduate students, as an integral part of the course (73-260, Fall 1995) "Introduction to Laboratory Animal Care and Management". 1997 - From Dr. Allan S. MacDonald (Professor of Surgery and Transplantation, Director of Transplant Programs & Services) to visit Dalhousie University/QE II Health Science Centre, and to initiate scientific cooperation between both our Centers in the medical/veterinary field of organ transplantation, on June 27, 1997. PRIZES AND GRANTS: 1976 - The Scientific Personnel Commission of the Scientific Council in the Centre of Experimental and Clinical Medicine of the Polish Academy of Sciences, Warsaw, Poland, supported a doctorate grant for the period from April 1, 1976 to March 31, 1977. SUBJECT: "The effect of hyperosmolar solutions on the metabolism of liver cells". 1984 - Dutch post-doctoral fellowship at the Department of Experimental Surgery and Central Animal Laboratory, Medical Faculty, University of Groningen, Holland, for the period from January 1, 1984 to Jan. 31, 1985. SUBJECT: "Bio-compatibility of biodegradable and non-biodegradable grafts implanted into trachea and oesophagus". 1990 - Canadian post-doctoral fellowship at the Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada, for the period from June 18, 1990 to June 18, 1991. SUBJECT: "Post/Flushing and Post/Ischemic Tissue Reperfusion Injury". 1991 - The Winner of the President's Award for the best abstract in the Biological Section of the 18th Annual Meeting of the Microscopical Society of Canada in Calgary, Alberta, Canada, June 23-26 entitled: "Light and electron microscopic assessment of autolysis of rat and dog pancreas stored at 4°C for up to 96 hours: The effects of fasting organ donors pre-operation, tissue dehydration during preservation and using low pH of flushing/preservation solutions". PAPERS PRESENTED at the CONGRESSES: Please refer to Appendix I. pp. 14-18 POSTGRADUATE COURSES & MEETINGS ATTENDED: Please refer to Appendix III. pp. 21-22 MISCELLANEOUS: 1. Ruka MP. Impact of hyperosmolar and hyperoncotic solutions on water distribution in organs to be transplanted. Ph.D. Thesis, 1980. 2. Ruka MP. The effect of isoosmolar, hyperosmolar and hyperoncotic solutions on rat pancreas storage at 4°C for up to 96 hours. RIG: University of Kuwait, Project No. MDT-177 (final report), 1987. 3. Ruka MP, Gareau P, Foster RA, Foster WG, Janzen EG. Development of a Rodent Model for Investigations of the Pathophysiology of Endometriosis: Application of MRI/MRS in the Assessment of Endometriotic Lesions (Contract Ref. No. 4622; Project No. K331219). Final report prepared for Dr. Warren G. Foster (Principal Investigator, Head, Reproductive Toxicology Section, Environmental Health Directorate, Health Canada, Ottawa, Ontario K1A 0L2), March 1995. ACKNOWLEDGEMENTS: 1. "Effect of Major Transfusions of Electrolytes, Glucose, and Dextran on the Pressure of Intraparenchymatous Liquid in the Lung Tissue". Department of Experimental Surgery, Centre of Experimental and Clinical Medicine of the Polish Academy of Sciences, Warsaw, Poland. (Principal investigator - Dr. A. Deszkiewicz). Thesis for a Ph.D. degree completed in 1976. 2. "Effect of Major Transfusions of Conserved Blood on the Respiratory System". Centre of Experimental and Clinical Medicine, Polish Academy of Sciences, Warsaw, Poland, Department of Experimental Surgery and Transplantation. (Principal investigator - Dr. J. Czajkowski). Thesis for a Ph.D. degree completed in 1976. 3. "Immunological Characteristics of Pre-lymph Node Cells". Department of Experimental Surgery and Transplantation, Centre of Experimental and Clinical Medicine of the Polish Academy of Sciences, Warsaw, Poland. (Principal investigator - Dr. H. Galkowska). Thesis for a Ph.D. degree completed in 1980. 4. "The level of Digoxin in Tissue and Body Fluids in Experimental Conditions and in the Course of Hypokalemia". The Clinic of Angiopathy, Institute of Internal Diseases, Medical Academy of Warsaw, Poland. (Principal investigator - Dr. W. Grzesiuk). Thesis for a Ph.D. degree completed in 1981. MEMBERSHIP IN PROFESSIONAL ASSOCIATIONS: - International Society of Lymphology, since 1980 - Polish Society of Surgery, since 1983 - Society for Organ Sharing, since 1988 - Microscopical Society of Canada, since 1990 - Canadian Transplantation Society, since 1993 - American Society of Transplantation - since 1998 (formerly the American Society of Transplant Physicians, formed in 1982) since 1995 - College of Veterinarians of Ontario (CVO) since 1995 - Xenotransplant Association since 1998 PUBLICATIONS: Please refer to Appendix I. pp. 9-13 Published 83 publications: - Original papers - 23 (8 as a first author) - Conference Presentations and Published Abstracts - 60 (39 as a first author) APPENDIX I LIST OF ORIGINAL ARTICLES (Published in Scientific and Clinical Journals): 1. Czajkowski J, Deszkiewicz A, Polanski J, Ruka M, Olszewski W. Anaesthesia for ortotopic allogenic liver transplantation in Pigs /in Polish/. Anest Reanim Intens Terap 1976; 8(3): 317-327. 2. Ruka M, Plachta J, Kupiec-Weglinski J, Olszewski W. Technique for long period cannulation of hepatic and portal veins in dogs /in Polish/. Pamietnik 48 Zjazdu Towarzystwa Chirurgow Polskich 1976, p. 573. 3. Ruka M, Plachta J, Olszewski W. Extracorporeal hemoperfusion through an activated charcoal column /in Polish/. Pamietnik 48 Zjazdu Towarzystwa Chirurgow Polskich 1976, p. 466-7. 4. Lukasiewicz H, Olszewski W, Ruka M. Pharmacological prolongation of the hyperacutely rejected xenografts /in Polish/. Pamietnik 48 Zjazdu Towarzystwa Chirurgow Polskich 1976, p. 565-6. 5. Olszewski W, Lukasiewicz H, Kossakowski A, Galkowska H, Ruka M. Inhibition of leukocyte migration by serum effluent from hyperacutely rejected xenografts. Transplantation 1976; 22(5): 526-528. 6. Dabrowska B, Ruka M, Walczak E. The electrocardiographic diagnosis of left septal fascicular block. Eur J Cardiol 1978; 6(5): 347-357. 7. Ruka MP, Olszewski WL. Lack of protective effects of hypertonic mannitol on ischemic kidney in dog. Acta Med Pol 1978; 19(1-2): 53-57. 8. Plachta N, Rowinski W, Ryffa T, Ruka M, Stepkowski S. Correlation of in vitro viability assays with the life supporting function of the ischemically damaged kidney. Acta Med Pol 1978; 19(1-2): 35-42. 9. Rowinski W, Ryffa T, Stepkowski S, Wozniewicz B, Ruka M, Wasowaska B, Hay M, Olszewski W. Active enhancement of dog kidney allografts using ALG and donor platelets. Arch Immunol Therap Exp 1978; 26: 1013 -1019. 10. Olszewski W, Stefanska E, Ruka M, Lukasiewicz H. Biological and biochemical characteristics of serum fraction effluent from xenografts and inhibiting leukocyte migration. Arch Immunol Therap Exp 1978; 26: 1083-1086. 11. Olszewski WL, Lukasiewicz H, Stefanska A, Wachal T, Ruka M. Immune complexes in serum of the hyperacutely rejected xenografts. Transplantation Proceedings, 1979; 11(2): 1410. 12. Olszewski WL, Ruka M. The effect of osmolality of washout solution. Organ Preservation, III Ed., D.E. Pegg, 1979, pp 124-131. 13. Rowinski W, Ryffa T, Stepkowski S, Ruka M, Wasowska B, Galkowska H. Prolongation of allogenic kidney graft survival using antilymphocyte globulin and donor antigen /in Polish/. Pol Przegl Chir 1980; 7a: 348-349. 14. Ruka MP, Olszewski WL. The effect of hyperosmolar solutions on thoracic duct lymph flow. Progress in Lymphology, Avicenum Czechoslovak Medical Press, Prague, 1981, pp 133-135. 15. Rowinski W, Ryffa T, Ruka M, Wasowska B, Tilney NL, Olszewski WL. Platelet - induced donor specific unresponsiveness to kidney allografts in mongrel dogs treated with ALG. Transplantation Proceedings 1981; 13(1): 586-588. 16. Szczepanska-Sadowska E, Ruka M, Sobocinska J, Kozlowski S. Suppression of thirst in dogs with arteriovenous fistula. Arch Internat Physiol Biochim 1981; 89: 269-273. 17. Ruka M, Olszewski WL. The influence of diuretics on lymph flow and composition from lymphoedematous tissues. Progress in Lymphology, Avicenum Czechoslovak Medical Press, Prague, 1982, pp 487-492. 18. Wachal T, Olszewski WL, Ruka M. Hyperacute rejection of xenografts. I. Arch Immunol Therap Exp 1983; 31: 231-235. 19. Wachal T, Olszewski WL, Ruka M. Hyperacute rejection of xenografts. II. Arch Immunol Therap Exp 1983; 31: 273-281. 20. Rowinski W, Ruka M, Stuart F, Buckingham F. Amelioration of the ischemic damage of the dog kidney subjected to 90 minutes of warm ischemia by lidocaine pretreatment and low-dose dopamine infusion on revascularization. Advances in Experimental Medicine and Biology, 1987; 212: 291-297. 21. Ruka MP, White AG, Kumar MSA, Al-Abdullah IH, Abouna GM. Change in the weight of pancreas during preservation in various solutions. Transplantation Proceedings, 1989; 21(1): 1372-1375. 22. Ruka MP, Tungekar MF, Kuit J, Hofstra W. A partial replacement of the oesophageal muscle layers by carbon -fibre prosthesis. Eur Surg Res 1991; 23(1): 35-45. 23. Foster, W.G., Ruka, M.P., Gareau P., Foster R.A., Janzen E.G., and Yang J.Z. Morphologic characteristics of endometriosis in the mouse model: application to toxicology. Canadian Journal of Physiology and Pharmacology, 1997; 75: 1188-1196. LIST OF CONFERENCE PRESENTATIONS (ORAL AND POSTER SESSIONS) AND PUBLISHED ABSTRACTS in Scientific and Clinical JOURNALS: 1. Ruka M, Plachta J, Olszewski WL. Extracorporeal hemoperfusion through an activated charcoal column /in Polish/. 48th Congress of the Polish Surgical Society, Warsaw, 1976, Abstracts, p.180. 2. Olszewski W, Ruka MP. Hyperosmolality as effector preventing ischemic changes in kidneys. International Symposium on Preservation and Storage of Organ and Tissues for Transplantation, Warsaw, 1977. 3. Benendo-Kapuscinska B, Ruka M. Experimental obstruction of ileum in dogs /in Polish/. 28th Congress of Polish Radiological Society, Wroclaw 1977, Abstracts, p 29. 4. Plachta N, Ryffa T, Ruka M, Rowinski W. A correlation of in vitro tissue viability assays with life-supporting function of ischemically damaged kidney. 12th Congress of the European Society for Surgical Research, Warsaw, Abstracts, Eur surg Res 1977; 9(1): 81. 5. Rowinski W, Ryffa T, Stepkowski S, Ruka M, Wasowska B, Galkowska H. Prolongation of allogenic kidney graft survival using antilymphocyte globulin and donor antigen /in Polish/. 49th Congress of the Polish Surgical Society, Torun, 1978. 6. Rowinski W, Ryffa T, Stepkowski S, Ruka M, Wasowska B, Galkowska H. Enhancing effect of donor platelets on kidney allograft survival in the unmatched mongrel dogs pretreated with ALG. XV Congress of the European Dialysis and Transplant Association, Istanbul, 1978, Abstracts, p.196. 7. Rowinski W, Ryffa T, Stepkowski S, Ruka M, Wasowska B, Galkowska, Olszewski W. Active enhancement of dog kidney allograft using ALG and donor platelets. 13th Congress of the European Society for Surgical Research, Helsinki, Abstracts, Eur surg Res 1978; 10(1): 8-9. 8. Olszewki WL, Lukasiewicz H, Wachal B, Ruka M. Immune complexes in the serum of hyperacutely rejected xenografts. Congress of the International Transplantation Society, Rome, 1978. 9. Olszewski WL, Ruka M. The effect of osmolality of wash-out solutions. Symposium of Organ Transplantation, Odensee, Denmark, April, 1978. 10. Ruka M, Olszewski WL. The effect of hyperosmolar solutions on thoracic duct lymph flow. Congress of Surgical Research, Zakopane, 1979, Abstracts, p 111. 11. Rowinski W, Ryffa T, Ruka M, Plachta N, Stepkowski S, Olszewski W. The use of specific and nonspecific immunosuppression for prolongation of dog kidney allograft survival. Congress of Surgical Research, Zakopane, 1979, Abstracts, p 96. 12. Ruka M, Olszewski WL. The effect of hyperosmolar solutions on thoracic duct lymph flow. 7th International Congress of Lymphology, Florence, 1979, Abstract, p 58. 13. Grzesiuk W, Ruka M, Preibisz J. Digoxine level in tissues and body fluids in hypokalemia: experimental studies /in Polish/. 3rd Congress of Polish Cardiological Society, Poznan, 1979, Abstracts, p 75. 14. Bilenko MB, Olszewski WL, Rowinski W, Ruka M, Murawska M, Lukomska B. Rabbit kidney xenograft in dogs as a hyperacute rejection model. 7th International Congress of Organs Transplantation, Baku, 1979. 15. Kozlowski S, Ruka M, Szczepanska-Sadowska E, Sobocinska J. Enhancement of osmotic thirst in dogs with arteriovenous fistulae. 7th International Conference on the Physiology of Food and Fluid Intake, Warsaw, 1980, Abstracts, p 45. 16. Ruka MP, Olszewski WL. The effect of postoperative infusion of hyperosmolar and hyperoncotic solutions on mobilization of water from the traumatized tissues. 15th Congress of the European Society for Surgical Research, Brussels, Abstracts, Eur surg Res 1980; 12: 47-48. 17. Rowinski W, Ryffa T, Ruka M. Platelets induced donor specific unresponsiveness to allogenic kidney in mongrel dogs treated with ALG. VIII International Congress of the Transplantation Society, Boston, 1980. 18. Ruka M. Whole body distribution of hyperosmotic and hyperoncotic solutions used as protectors in donors' organs. IV Symposium fur Experimentelle Urologie, Rostock-Warnemunde, 1981. 19. Ruka M, Olszewski WL. The influence of diuretics on lymph flow and composition from lymphoedematous tissues. 8th International Congress of Lymphology, Montreal 1981, Abstract p 44. 20. Ruka M, Olszewski WL. Influence of hyperoncotic fluid infusion on wound water content. 8th Quadrilateral Congress of Experimental Surgery, Budapest, 1981, Abstracts, p 38. 21. Ruka M. Kunstliche Drainage im Ductus thoracicus. (in English). V Symposium uber Experimentelle Urologie, Rostock-Warnemunde, 1983. 22. Ruka M, Przeor A, Olszewski W. Permeability of lymph vessels and nodes. Hungarian Experimental Surgical Congress, Debrecen, 1983, Abstracts, p 33. 23. Ruka M, Olszewski W. Influence of hyperosmolar fluids on wound water content (in Polish). 51st Congress of the Polish Society of Surgery, Lodz, Poland, 1983, Proceedings pp 338-347. 24. Ruka M, Przeor A, Olszewski W. Permeability of lymph vessels to proteins. 9th Congress of Lymphology, Israel, 1983, Abstracts, p 86. 25. Ruka M, Rowinski WA, Plachta S, Morzycka M, Smogorzewski M. Lignocaine pretreatment and constant dopamine infusion protects dog kidney against ischemic damage. 19th Congress of the European Society for Surgical Research, Zurich, Abstracts, Eur surg Res 1984; 16(1): 76. 26. Ruka M, Rowinski WA, Lipski M, Wasiutynski A, Olszewski W. Expanded P.T.F.E. Grafts in restoring bile drainage in dogs. 20th Congress of the European Society for Surgical Research, Rotterdam, Abstracts, Eur Surg Res 1985; 17(1): 77-78. 27. Ruka MP, Kuit J, Hofstra W, Tungekar F, Wildevuur ChRM, Koers R, Heikamp A. Total Reconstruction of the Rabbit Trachea by Implanted a Poly-Ether-Urethane Prosthesis. International Symposium on Biotechnology in Clinical Medicine, Rome, 1987, Abstracts, p 231. 28. Ruka MP, Kuit J, Hostra W, Tungekar F, Wildevuur ChRM, Koers R, Heikamp A. A Carbon-Fiber Material as a Functional Adequacy of Oesophageal Muscle Layer. International Symposium on Biotechnology in Clinical Medicine, Rome, 1987, Abstracts, p 230. 29. Ruka MP, Kuit J, Tungekar F, Wildevuur ChRM. The Oesophageal Muscle Layer Reconstruction by Implanted a Carbon-Fiber Prosthesis. XXIII World Veterinary Congress, Montreal, 1987, Abstracts, p 192. (Invited lecture) 30. Ruka MP, Kuit J, Hofstra W, Tungekar MF, Wildevuur ChRM. A partial replacement of the rabbit trachea by implantation of a poly-ether-urethane (P.E.U.) prosthesis. International Society for Artificial Organ, Abstracts, Rostock - Warnemunde, 1987. 31. Ruka MP, Kumar MSA, White AG, Abouna GM. The effect of isoosmolar, hyperosmolar and hyperoncotic preservation solutions on rat pancreas stored at 4 degrees C for up to 96 hours. First International Congress on Pancreatic and Islet Transplantation, Stockholm, Sweden, 1988, Abstracts, p 94; Diabetes 1989; 38(S1): 241. 32. Al-Abdullah IH, Kumar MSA, Ruka MP, Abouna GM. Isolation of rat pancreatic islets of Langerhans using Trowell's TS medium. First International Congress on Pancreatic and Islet Transplantation, Stockholm, Sweden, 1988, Abstracts, p 149; Diabetes 1989; 38(S1): 273. 33. Al-Abdullah IH, Kumar MSA, Ruka MP, Abouna GM. Successful islets transplantation using cyclosporin in outbred sprague-dawling rats. XII International Congress of the Transplantation Society, Sydney, Australia, 1988, Poster Abstract Book, p 90. 34. Ruka MP, Kumar MSA, White AG, Abouna GM. Changes in the wet weight of pancreas during preservation in various solutions. XII International Congress of the Transplantation Society, Sydney, Australia, 1988, Oral Abstract Book, p 298 (Oral presentation) 35. Ruka MP, Mathews KA, Hulland TJ, Winter CA, Butler, DG. Light and electron microscopic assessment of autolysis of rat and dog pancreas stored at 4°C for up to 96 hours. The effects of fasting organ donors pre -operation, tissue dehydration during preservation and using low pH flushing/preservation solutions. 18th Annual Meeting of the Microscopical Society of Canada, Calgary, Alberta, Canada, Proceedings 1991; 18: 110-111. (Poster presentation) * The Winner of the President's Award in Biological Section of MSC/SMC. 36. Ruka MP, Hulland TJ, Mathews KA, Winter CA, Butler DG. Suppressed autolysis of rat/dog pancreas during simple long-term (96 hours) cold storage (4°C) in Belzer UW-CSS and Minnesota human pancreas perfusate (Minn. HPP) solutions correlated with tissue dehydration. The Royal College of Physicians and Surgeons of Canada, the 60th Annual Meeting, and the Canadian Transplantation Society Annual Meeting, Quebec City, Quebec, Canada, 1991, Clinical and Investigative Medicine 1991; 14(4): A138-858. (Poster presentation) 37. Ruka MP, Mathews KA, Von Althen N, Butler DG. Rat and dog pancreas tissue-water loss (dehydration) in Belzer UW-CSS and Euro-Collins solutions following long-term cold ischemia (4°C). The Royal College of Physicians and Surgeons of Canada, the 60th Annual Meeting, and the Canadian Transplantation Society Annual Meeting, Quebec City, Quebec, Canada, 1991, Clinical and Investigative Medicine 1991; 14(4): A138-859. (Poster presentation) 38. Mathews KA, Ruka MP, Hulland TJ, Butler DG. The effect of low or high pH flushing/preservation solutions (Belzer UW-CSS and 0.9% NaCl) on rat pancreas stored at 4°C for up to 96 hours. The Royal College of Physicians and Surgeons of Canada, the 60th Annual Meeting, and the Canadian Transplantation Society Annual Meeting, Quebec City, Quebec, Canada, 1991, Clinical and Investigative Medicine 1991; 14(4): A138-860. (Poster presentation) 39. Mathews KA, Ruka MP, Hulland TJ, Black F, Butler DG. Evidence that fasting of donor rats adversely affects pancreas tissue-water content during preservation by simple cold storage at 4°C for up to 96 hours. The Royal College of Physicians and Surgeons of Canada, the 60th Annual Meeting, and the Canadian Transplantation Society Annual Meeting, Quebec City, Quebec, Canada, 1991, Clinical and Investigative Medicine 1991; 14(4): A138-861. (Poster presentation) 40. Ruka MP, Hulland TJ, Mathews KA, Janzen EG, Butler DG. The effect of three cold storage solutions on rat and dog pancreas and kidney tissue-water content and morphology. The Royal College of Physicians and Surgeons of Canada, the 61st Annual Meeting, and the Canadian Transplantation Society Annual Meeting, Ottawa, Ontario, Canada, 1992, Clinical and Investigative Medicine 1992; 15(4): A149-940. (Poster presentation) 41. Ruka MP, Hulland TJ, Mathews KA, Janzen EG, Butler DG. Suppression of tissue edema by potassium lactobionate (PLA) correlates with suppression of tissue autolysis in long-term cold stored rat pancreas. The Royal College of Physicians and Surgeons of Canada, the 61st Annual Meeting, and the Canadian Transplantation Society Annual Meeting, Ottawa, Ontario, Canada, 1992, Clinical and Investigative Medicine 1992; 15(4): A152-957. (Poster presentation) 42. Towner, RA, Ruka MP, McCutcheon J, Butler DG, Janzen EG. Changes in ex vivo pre-transplantation tissue PME/ß-ATP ratios in pig and dog kidney using 31P-MRS do not correlate with pre-transplantation tissue morphology and tissue hydration status indicators of organ function post-transplantation. 20th Annual Meeting of the Microscopical Society of Canada, Toronto, Ontario, Canada, June 3-5, 1993. Proceedings 1993; 20: 170-171. (Poster presentation) 43. Ruka MP, Hulland TJ, Mathews KA, Janzen EG, Butler DG. Selected factors conserve rat pancreas morphology when organ exposed ex vivo to long-term cold ischemia. 20th Annual Meeting of the Microscopical Society of Canada, Toronto, Ontario, Canada, June 3-5, 1993. Proceedings 1993; 20: 158-159. (Poster presentation) 44. Ruka MP, Hulland TJ, Mathews KA, Janzen EG, Butler DG. Fasting donor rat and use of Belzer but not 0.9% NaCl for flushing and storage enhances resistance to cold ischemic injury. First Joint Conference of the Canadian Transplantation Society and the Canadian Association of Transplantation, Whistler, British Columbia, Canada, September 9-11, 1993, Abstracts p 32, Clinical and Investigative Medicine 1993; 16(4): B139-863. (Poster presentation) 45. Towner RA, Ruka MP, McCutcheon J, Butler DG, Janzen EG. Use of (31P)-MRS for Pre-transplant assessment of pig and dog kidney viability: No correlation with tissue PME/Pi or PME/ß-ATP ratios. First Joint Conference of the Canadian Transplantation Society and the Canadian Association of Transplantation, Whistler, British Columbia, Canada, September 9-11, 1993, Abstracts p 38, Clinical and Investigative Medicine 1993; 16(4): B140-864. (Poster presentation) 46. Ruka MP, Mathews KA, Butler DG. Introduction to the University of Guelph Xenotransplantation Group. First Joint Conference of the Canadian Transplantation Society and the Canadian Association of Transplantation, Whistler, British Columbia, Canada, September 9-11, 1993, Abstracts p 38, Clinical and Investigative Medicine 1993; 16(4): B140-865. (Poster presentation) 47. Gareau PJ, Ruka MP, Reinke LA, Butler DG, Janzen EG. The use of MRI and spin trapping to study CCL4-induced hepatotoxicity in rats implanted with Guyton's sphere. 4th International Symposium on Spin Trapping and Organic EPR Spectroscopy with Applications in Chemistry, Biology and Medicine, Oklahoma City, Oklahoma, USA, October 24-28, 1993. Abstracts book. (Poster presentation) 48. Ruka MP, Butler DG, McCutcheon J, Mallard BA, Janzen E, Cockshutt J, Miller C, Plante C. Xenotransplantation: Pig kidney to dog. 21st Annual Meeting of the Microscopical Society of Canada, Montreal, Quebec, Canada, June 12 -15, 1994. Proceedings 1994; 21: 60-61. (Oral presentation) 49. Ruka MP, Hulland TJ, Mathews KA, Butler DG. Better preservation of the rat pancreas morphology in dextran (MW 2,000,000) than in Belzer UW-CSS after 96 hrs of simple cold (4°C) storage. 21st Annual Meeting of the Microscopical Society of Canada, Montreal, Quebec, Canada, June 12-15, 1994. Proceedings 1994; 21: 100-101. (Oral presentation) 50. Ruka MP, Butler DG, Mallard BA, McCutcheon J, Janzen E, Cockshutt J, Miller C, Plante C. Xenotransplantation: Pig kidney to dog. Strategies for Successful Xenotransplantation-IBC USA Conference, Washington, DC, USA, June 16-17, 1994. (Poster presentation) 51. Ruka MP, Mathews KA, Hulland TJ, McCutcheon J, Butler DG. The effect of tissue dehydration with dextran (MW 2,000,000) on suppression of tissue edema, and abrogration of tissue autolysis in long-term (96 hrs) cold stored (4°C) rat pancreas. 63rd Annual Meeting of The Royal College of Physicians and Surgeons of Canada, Canadian Society of Nephrology, Toronto, Ontario, Canada, September 14-19, 1994, Clinical and Investigative Medicine 1994; 17(4): B99-584. (Poster presentation) 52. Ruka MP, McCutcheon JL, Butler DG. 50% decrease in hydrostatic pressure during initial flushing of rat pancreas decreased tissue edema during short- and long-term cold (4°C) storage. 64th Annual Meeting of The Royal College of Physicians and Surgeons of Canada, Canadian Society of Nephrology, Montreal, Quebec, Canada, September 13-17, 1995, Clinical and Investigative Medicine 1995; 18(4): B96-633. (Poster presentation) 53. Ruka MP, Hulland TJ, Janzen EG, Butler DG. Lack of protective effect of the -COOH group and the MW 307 of glutathione. 64th Annual Meeting of The Royal College of Physicians and Surgeons of Canada, Canadian Society of Nephrology, Montreal, Quebec, Canada, September 13-17, 1995, Clinical and Investigative Medicine 1995; 18(4): B96-634. (Poster presentation) 54. Ruka MP, McCutcheon JL, Gareau PJ, Foster WG, Janzen EG. Evaluation of estrogen/progesterone treatment on the functional integrity of the endometrium temporally exposed to warm ischemia prior to its auto -transplantation. 64th Annual Meeting of The Royal College of Physicians and Surgeons of Canada, Canadian Association of Pathologists, Montreal, Quebec, Canada, September 13-17, 1995, Clinical and Investigative Medicine 1995; 18(4): B11-723. (Oral presentation) 55. Ruka MP, McCutcheon JL, Gareau PJ, Foster WG, Janzen EG. Surgically induced model of endometriosis in B6C3F1 mice. 64th Annual Meeting of The Royal College of Physicians and Surgeons of Canada, Canadian Association of Pathologists, Montreal, Quebec, Canada, September 13-17, 1995, Clinical and Investigative Medicine 1995; 18(4): B11-723. (Poster presentation) 56. Ruka MP, Foster RA, Butler DG. 50% decrease in hydrostatic pressure during initial flushing of rat pancreas significantly reduced tissue edema during short- and long-term cold (4°C) storage. Joint Annual Meeting of the Canadian Association of Transplantation and the Canadian Transplantation Society, Montreal, Quebec, Canada, September 13-17, 1995. Scientific Abstract Book p 41, abstract no. 30. (poster presentation) 57. Ruka MP, Hulland TJ, Janzen EG, Butler DG. Involvement of the receptor but not the -COOH group or the MW of potassium lactobionate in long-term (96-hrs) cold stored (4°C) rat pancreas. Joint Annual Meeting of the Canadian Association of Transplantation and the Canadian Transplantation Society, Montreal, Quebec, Canada, September 13 -17, 1995. Scientific Abstract Book, p 45, abstract no. 40. (Poster presentation) 58. Ruka MP, Plante C, Mallard BA, Foster RA, Cockshutt, Miller C, Abrams-Ogg ACG, Janzen EG, Butler DG. Accuracy and fate of Ultrasound -guided injection of activated charcoal into the neck and peritoneal cavity of the 56-day-old fetal pig. Joint Annual Meeting of the Canadian Association of Transplantation and the Canadian Transplantation Society, Montreal, Quebec, Canada, September 13-17, 1995. Scientific Abstract Book, p 42, abstract no. 32. ( poster presentation) 59. Foster WG, Ruka MP, Foster RA, Janzen EG. Histopathological characteristics of endometrial implants in a new mouse model of endometriosis. (submitted) 60. Ruka MP, Plante C, Mallard BA, Abrams-Ogg ACG, Butler DG. Pig/dog chimerism (50/50) detected in the peripheral blood lymphocytes (PBL) of pig-fetus at 105 days of gestation. 67th Annual Meeting of The Royal College of Physicians and Surgeons of Canada, Canadian Association of Pathologists, Toronto, Ontario, Canada, September 24-27, 1998, (poster presentation), Clinical and Investigative Medicine 1998; (Supplement) S81: 393 APPENDIX II Number of Operations Laboratory Performed from 1974 Index Experimental Operations * Animal ** to present 1 Long-term portal and hepatic veins cannulation dog 126 2 Liver preservation and transplantation dog/pig 40 3 Liver denervation dog 5 4 Liver bacteriology dog 6 5 Hemoperfusion through an activated charcoal column dog 30 6 Experimental common bile duct obstruction dog 24 7 Implantation of the Gore Tex prosthesis into common bile duct dog 24 8 Heart transplantation dog 6 9 Experimental interruption of the heart left bundle divisions dog 41 10 Kidney Auto- and Allo- transplantation *** dog 253 11 Experimental renal hypertension dog 18 12 Ileum transplantation dog 10 13 Experimental ileum obstruction dog 45 14 Experimental ileum edema dog 20 15 Thoracic duct cannulation dog 252 16 Gore-Tex prosthesis implantation into thoracic duct and femoral vein dog 23 17 Ileum and liver lympathic vessels cannulation dog 34 18 Lymphatic vessels and lymph node perfusion -in vivo dog 57 19 Lymph node transplantation dog 6 20 Leg afferent and efferent lymph vessels cannulation dog 135 21 Experimental lymphoedema (Elephantiasis) dog 75 22 Lymphatic vessel to vein vessel implantation dog 7 23 Arteriovenous fistula (Aorta to V.Cava) dog 8 24 Liver and kidney rabbit-to-dog xenograft transplantation rabbit/dog 124 25 Skin transplantation dog 54 26 Thymectomy in puppies dog 5 27 Interstitial fluid pressure measurement (Guyton's sphere implantation into the lung and subcutaneously) dog 30 28 Bone-like material implantation to the femoral bone dog 21 29 Oesophageal muscular layers reconstruction by a carbon-fiber prostheses implantation rabbit 75 30 Trachea reconstruction by implanted P.E.U. prostheses rabbit 19 31 Urinary bladder wall reconstruction using the PLL/PU membrane rabbit 8 32 Artificial lenses implantation into cornea rabbit 6 33 Rat pancreas preservation (96 hrs) for transplantation rat 314 34 Pancreas allo-transplantation (cuff technique) from white Wistar-donor to BB-rat recipient rat 12 35 Total pancreatectomy in Yellow Baboon to induce diabetes and for islets of Langerhans isolation monkey 5 36 Canine liver allo-transplantation dog 4 37 Canine pancreas preservation (96 hrs) for transplantation dog 27 38 Canine kidney preservation (96 hrs) for transplantation dog 37 39 Piglet kidney preservation (96 hrs) for transplantation piglet 9 40 Pig-to-dog kidney xenograft transplantation piglet/dog 4 41 Pig-to-pig kidney autograft transplantation piglet 3 42 Guyton's sphere implantation into rat’s liver rat 12 43 Model of endometriosis in B6C3F1 mice mouse 51 44 Model of partially sialoadenectimized rats rat 54 45 Cannulation of Ductus Thoracicus in rats rat 3 46 Surgical vs. MRI evaluation of polycystic kidneys in DBA/2 FG-pcy mice (female and male) mouse 5 47 Gnotobiotic Surgery (caesarian section; pathogen free)**** pigs/fetuses 10 ______________________________________________________________________________ TOTAL 2,137 ___________________________________________________________________ * This List does not include operations which were performed in clinical small animal-patients (dogs and cats) such as: ovariectomy, ovariohysterectomy, testectomy, prostatectomy, mastectomy, penile amputation, enterectomy, gastric torsion, bone fracture, patellar reposition, hip dysplasia, extirpation of anal glands etc. (Holland, Poland, Canada) ** Dog - mongrel dog, Beagle; pig - white domestic pig, Duroc - wild Iraqi pig and MHC defined miniature pig (Guelph, Ontario, - colony); monkey - Yellow Baboon, Rhesus Macaques; rabbit -white New Zealand; rat - White Wistar, BB -rat - spontaneously diabetic; mouse - strain B6C3F1 and DBA/2 FG-pcy *** (a) Kidney auto-transplantation after warm (60, 90, and 120 min. in abdominal cavity) or cold (24 hrs. in 4°C) storage. (b) Kidney allo-transplantation with various protocols of immunosuppression to abrogate or in some specific protocols to enhance graft rejection. **** Surgery carried out on transgenic pigs created by using embryo-transfer technology established at the University of Guelph (in 1997-1999, Ontario Veterinary College) for the purpose of delivering piglets expressing human genes following protocol(s) established by Dr. White of Immutran Inc. (Cambridge, England). This program was brought into existence, supervised and fully financially sponsored by NOVARTIS Pharmaceutical Corporation. APPENDIX III POSTGRADUATE COURSES AND MEETINGS ATTENDED: 1. Microvascular Surgery Training, Central Animal Laboratory, Medical Faculty, Groningen, Holland, April-May 1984. 2. Experimental Eye Surgery, Dr. Jan Worst Research Group, Groningen, Holland, March-July 1985. 3. Training Course in Safe Handling of Radioactive Materials organized by Dr. Azuwuike Owunwanne, Department of Nuclear Medicine at the Faculty of Medicine, Kuwait University Health Science Centre, Kuwait, October 11-15, 1986. 4. An International Symposium on Bio-ethics and Applied Ethnology, Montreal, Canada, August 15-16, 1987. 5. Introduction to Computers and VAX-VMS, course organized by Drs. H. Razouki and S. Malki at the Computer Unit, Faculty of Medicine, Kuwait University, Kuwait, April 16-20, 1988. 6. An Educational Course on Tissue and Organ Transplantation, Sydney, Australia, August 13-14, 1988. 7. Second Kuwait International Symposium on Ophthalmology, Kuwait, February 3-7, 1989. 8. Innovations in vascular surgery: Laser vascular surgery and vascular prosthesis. Seminar organized by Dr. R. Guidoin, University Laval, Quebec City, Canada, November 17, 1989. 9. Electron microscopic picture of tissue reactivity when biomaterial grafts are implanted into soft and hard tissues. Seminar organized by Dr. R. Guidoin, Institut de génie des matériaux -CNCR Boucherville, Montreal, Canada, September 29, 1989. 10. "Oxygen stress" workshop organized by Dr. E.G. Janzen at the Department of Clinical Studies, OVC, University of Guelph, Guelph, Ontario, Canada, December, 1990. 11. "MRI in animal research for agriculture, veterinary medicine and biological models." Workshop organized by Dr. E.G. Janzen at the Department of Clinical Studies, OVC, University of Guelph, Guelph, Ontario, Canada, June 17, 1991. 12. American Society of Transplant Physicians, 10th Annual Meeting at Fairmont Hotel, Chicago, Illinois, USA, May 28 -29, 1991. 13. American Society of Transplant Surgeons, 17th Annual Meeting at Fairmont Hotel, Chicago, Illinois, USA, May 29 -31, 1991. 14. First International Congress on Xenotransplantation, Minneapolis, Minnesota, USA, August 25-28, 1991. 15. International (second) Symposium on Small Bowel Transplantation, University Hospital in London, Ontario, Canada, October 3-5, 1991. 16. American Society of Transplant Physicians, 11th Annual Meeting, Chicago Hilton and Towers, Chicago, IL, USA, May 26-27, 1992. 17. American Society of Transplant Surgeons 18th Annual Meeting, Chicago Hilton and Towers, Chicago, IL, USA, May 27-29, 1992. 18. Molecular biology in organ transplantation. ASTP/ASTS Upjohn Symposium, Chicago Hilton and Towers, Chicago, IL, USA, May 26, 1992. 19. Immunosuppression and highlights in transplantation. The third ASTS postgraduate course, Chicago Hilton and Towers, Chicago, IL, USA, May 29-30, 1992. 20. MRI - User - Seminar; Organized by Dr. E.G. Janzen, University of Guelph, Arboretum, 3rd December, 1992. 21. First ASTP Satellite Basic Science Symposium Transplantation Immunobiology, Sheraton Chicago Hotel and Towers, Chicago, IL, USA, May 15, 1994. 22. American Society of Transplant Physicians, 13th Annual Meeting, Sheraton Chicago Hotel and Towers, Chicago, IL, USA, May 16-18, 1994. 23. ASTP/ASTS Joint Symposium, High-risk transplantation (cytomegalovirus infection). Sheraton Chicago Hotel and Towers, Chicago, IL, USA, May 18, 1994. 24. American Society of Transplant Surgeons, 20th Annual Meeting, Sheraton Chicago Hotel and Towers, Chicago, IL, USA, May 18-20, 1994. 25. Fifth ASTS Postgraduate Course, Sheraton Chicago Hotel and Towers, Chicago, IL, USA, May 20-21, 1994. 26. "Coping with Animal Mortality in Research and Teaching". Workshop organized by Human Resources at the Central Animal Facility (lectures delivered by Dr. Denna Benn and Dr. Cindy Adams), University of Guelph, Guelph, Ontario, Canada, April 5, 1995. 27. "Preventing Animal Related Diseases in People". Workshop organized by Human Resources (lectures delivered by Dr. John Prescott), at the Central Animal Facility, University of Guelph, Guelph, Ontario, Canada, April 25, 1995. 28. The 4th International Congress for Xenotransplantation, Nantes, France, September 7-11, 1997. 29. TRANSPLANTATION 1999 – Comprehensive Update and Review, The Westin Harbor Castle, Toronto, Ontario, Canada, July 30-August 1, 1999. 30. Focus Group Meeting to Maintain the Quality of Veterinary Practice organized by Harry Cummings & Associates Inc. Consulting Group, at the Guelph Youth Music Centre located at 75 Cardigan Street in Guelph, Ontario, Canada, Monday January 17, 2005. |
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