Dr. Ruka Canada
The CMVS is a clinical, teaching, research with diagnostic labs and services CENTER established to
assess the strategies to be undertaken by professionals in their fields of expertise (veterinary, human
medicine, biology, etc.) in organ/tissue/stem cells transplantation/regeneration, oncology, and genome
for the public health - the benefit of humans and animals
Copyright 2016 © The Cambridge Center for Medical & Veterinary Sciences Inc. (CCMVS). All rights reserved.
TM

                                                                 Curriculum Vitae

                                                          
 MIROSLAW P. RUKA

                                                                                                       D.V.M., Ph.D.


Total Number of Words Published (TWP): 8,906


















































                                                                                                Address for correspondence:

                                                                                                    Dr. Miroslaw P. Ruka
                                                                                              
Professor Veterinary Surgery
                                                  THE CAMBRIDGE CENTER FOR MEDICAL & VETERINARY SCIENCES INC.
                                                                          55 Yarmouth Street, Suite 204, Guelph, Ontario, N1H 7R4
                                                                                                                 Canada
                                                                                                 
http://www.CCMVS.com
                                       Telephone / Fax : (519) 763-9192                                                     E-mail: mp.ruka@ccmvs.com



PERSONAL:

Place of Birth:                   Warsaw, Poland
Citizenship:                       Canadian
Country of residence:        Canada (since July 1989 – present)

Address of permanent       204-55 Yarmouth Street
              residence:       Guelph, Ontario N1H 7R4, Canada
                                     Tel.: / Fax: (519) 763-9192

Present address of        THE CAMBRIDGE CENTER FOR MEDICAL & VETERINARY SCIENCES INC.
   employment:       55 Yarmouth Street, Suite 204, Guelph, Ontario N1H 7R4, Canada
                               Telephone: / Fax: (519) 763-9192
                                http://
www.CCMVS.com
                                E-mail: mp.ruka@ccmvs.com


EDUCATION:

1964-68      -High School; J. Slowacki - Lyceum No. 7, Warsaw, Poland
1968-74      -Warsaw Veterinary School, Faculty of Veterinary Medicine, Academy of Agriculture, Warsaw, Poland
1974           -Degree: Doctor of Veterinary Medicine (D.V.M.) obtained from the Warsaw Veterinary School, Faculty of
           Veterinary Medicine, University of Agriculture and Ministry of Agriculture in Warsaw, Poland, to practice a
           veterinary medicine as a General Veterinary Practitioner in its entirety.
1975-80     -Degree: Doctor of Natural Science (Ph.D.) in Experimental Medicine obtained from the Polish Academy of
           Sciences, Faculty of Medicine, Medical Research Centre, Warsaw, Poland
           Title of Ph.D. Thesis:
"Impact of Hyperosmolar and Hyperoncotic Solutions on Water Distribution in
           Organs to be Transplanted"
.


VETERINARY LICENSES:

1974        Polish Licence: to practice as a Doctor of Veterinary Medicine (D.V.M.) in the field of veterinary medicine in its
       entirety.

1985        
Dutch license: to practice as a Doctor of Veterinary Medicine (D.V.M.), signed by Her Majesty Beatrix, Queen of
       The Netherlands, etc., etc., obtained with admission to the Practice of Veterinary Medicine in its entirety from the
       Faculty of Veterinary Medicine, University of Utrecht, and Ministry of Agriculture and Fisheries in The Hague,
       Holland.

1995       
Canadian license: obtained with admission to the Veterinary Medicine Practice as a Veterinary Small Animal
      Organ Transplant Surgeon
(Restricted), issued by the Registration Committee of the College of Veterinarians of
      Ontario (CVO) - license no. 4796.


MAJOR FIELDS OF SPECIALIZATION:

  Clinical and comparative medical and veterinary small animal organ/tissue transplantation / physiology and immunology


SPECIAL FIELDS OF SPECIALIZATION FOR Ph.D.:

  Small animal soft tissue surgery, organ transplantation, organ preservation, organ procurement, and transplantation related
      immunology


LANGUAGES:        English; Polish



PRESENT POSITION(S) held at:
 The Cambridge Center For Medical & Veterinary Sciences Inc.(CCMVS):
  Faculty Member:                - Professor Veterinary Surgery
  Senior Executive Positions:         - Chairperson
                                                      - 1st Director
                                                      - President and Secretary
                                                      - Voting Member of the Board of Directors,
                                                      - Founder & Owner
 International Clinical & Comparative Medical & Veterinary Sciences Journal (ICCMVS):
                                                - Publisher
                                                - Founder & Owner


THE HISTORY OF EMPLOYMENT:

*  DEPARTMENT OF EXPERIMENTAL SURGERY & TRANSPLANTATION, Medical Research Centre, Polish
Academy of Sciences, Faculty of Medicine, Warsaw, Poland
Dr. W.A. Rowinski - Professor of Transplant Surgery
Dr. W.L. Olszewski - Professor of Transplant Surgery & Chairperson
              -From May 1975 to December 1984; Scientific Positions (in transplant/experimental surgery):
             - 1975-1980 - Assistant; 1980-1984 - Adjunct=Associate Professor of Experimental (Transplant) Surgery

*  DEPARTMENT OF EXPERIMENTAL SURGERY, Faculty of Medicine, University of Groningen, Groningen,
Holland (Dr. Ch.R.M. Wildevuur - Professor of Surgery & Chairperson;)
            -From January 1984 to January 31, 1985; Scientific Position: Post-Doctoral Fellowship

*  CENTRAL ANIMAL LABORATORY, Faculty of Medicine, University of Groningen, Groningen, Holland;
(Dr. H. Dikken - Director of the C.A.L);
           -From January 1984 to January 31, 1985; Scientific Position: Post-Doctoral Fellowship

*  THE VETERINARY SMALL ANIMAL CLINIC; M.A. van Messel and J.D.Th. Straatman, Groningen, Holland
          -From August 1985 to August 31, 1986; Position: Veterinary Small Animal Surgeon (Surgery)

*  DEPARTMENT OF ORGAN TRANSPLANTATION, Faculty of Medicine, Kuwait University, Kuwait
(Dr. G.M. Abouna - Professor of Transplant Surgery and Chairperson)
          -From August, 1986 to August 31, 1989;
           Scientific Position: Assistant Professor of Experimental (Transplant) Surgery.

*  DEPARTMENT OF CLINICAL STUDIES, Faculty of Veterinary Medicine, Ontario Veterinary College, University
of Guelph, Guelph, Ontario, Canada
(Dr. D.G. Butler - Professor of Medicine and Chairperson);
        -From June 1990 to June 18, 1991;
          Scientific position: Post-Doctoral Fellowship (in Transplant Surgery)
       -From June 19, 1991 to June 1997.
         Scientific position: Associate Research Scientist in Experimental (Transplant) Surgery

*  THE CENTRE OF CLINICAL & COMPARATIVE MEDICINE INC. (CCCM), Guelph, ON, Canada;
(Mr. Ronald W.P. Struthers - C.E.O. & President)
Positions held-from June 1997 to November 6, 1998:
06-1997 to 1998         Professor of Clinical Small Animal Transplant Surgery & Experimental Surgery
06-1997 to 1998         Director, Clinical Small Animal Organ Transplant Programs  & Services
06-1997 to 1998         Director, Xenotransplant Programs & Services
  to Nov. 1998         Vice-President for Research and Senior Chief Scientific Officer


*  THE CAMBRIDGE CENTER FOR MEDICAL & VETERINARY SCIENCES INC. (CCMVS);
Guelph, ON, Canada (http://www.CCMVS.com); Dr. M.P. Ruka, Founder & Owner;
Position(s) held from November 26, 1998 to present:
Professor Veterinary Surgery; 1st Director; Chairperson of the Board of Directors; Voting Member of the Board of
Directors; President and Secretary; Founder & Owner

*  THE GUELPH ANIMAL HOSPITAL (GAH, Guelph, Ontario, Canada)
Dr. Robert Butler - Director and Owner
Position(s) held: Veterinary Small Animals Soft Tissue Surgeon (Surgery)
From January 15, 2003 to November 01, 2010

* CLINICAL & COMPARATIVE MEDICAL & VETERINARY SCIENCES JOURNAL (ICCMVS), Guelph, Ontario, Canada
(www.CCMVSJOURNAL.com); Dr. M.P. Ruka, Founder & Owner;
Position(s) held from July 10, 2007 to present: Publisher; Founder & Owner




MAJOR FIELDS OF CLINICAL, APPLIED AND BASIC RESEARCH INTERESTS:

(1.) CLINICAL ORGAN TRANSPLANTATION: kidney and pancreas allograft transplantation into uremic or/and diabetic
patients (dogs and cats), particularly:
-        selection of the donor and donor-recipient matching system
-        donor pre-treatment, "untouched" organ harvesting technique and cold storage for transplantation
-        selection of flushing/preservation solution for temporally cold (4°C) storage
-        recipient pre-treatment prior to organ transplantation
-        treatment of post-reperfusion injury
-        recipient post-operative management
-        induction of the modern immunosuppressive protocol to prevent acute or chronic rejection of transplanted organ
        and to achieve its permanent accommodation (transplantation tolerance)
-        selection of antibiotic therapy
-        short- and long-term evaluation of graft(s) functional survival post-transplantation

(2.) EXPERIMENTAL SOLID ORGANS / TISSUES PRESERVATION & TRANSPLANTATION (liver, kidney,
pancreas, islet cells, heart, lungs, ileum) in animals, such as dogs, pigs, rabbits, rats, particularly:
-   suppression of the harmful effect of warm and cold ischemia on stored organs prepared for transplantation (e.g.
   dehydration phenomenon, and/or Ca++ channel blockers).
-   mechanism of tissue fluid formation and its transport through the capillary wall and across the interstitial space in
   ischemic tissue(s).
-   post-transplantation flushing/ischemic reperfusion injury and tissue inflammatory response in organs exposed to short
   and long-term warm/cold ischemia (eg. generation of free radicals, IL-1; IL-6 and other cytokines; TNF; adhesion
   molecules; ß-thromboglobulin), and their effects on acute and/or chronic tissue rejection in auto-, allo- and xeno-graft
   models of kidney transplantation.

(3.) XENOGENIC TRANSPLANTATION OF SOLID ORGANS & TISSUES IN DISCORDANT ANIMALS:
The mechanism of hyperacute/acute - vascular/tissue rejection in immediately or cold (4°C) stored vascularized kidney
xenograft transplanted from:
-  unmodified pig-donor to modified (any)-recipient by: immunosuppression (CsA, brequinar sodium, etc.),
 plasmapheresis, donor bone marrow, total body irradiation, splenectomy, etc.
-  modified pig-donor to modified (any)-recipient: e.g. production of transgenic/chimeric pig/(recipient)
-  modified pig-donor to unmodified (any)-recipient, particularly: to overcome the problem of hyper/acute and/or
accelerated vascular/tissue rejection and to achieve a permanent accommodation of the xenograft.

(4.) ORGAN RECONSTRUCTION:
Functional reconstruction of the bile duct, oesophagus, trachea, urinary bladder,
cornea (intracorneal lenses) and continuity of the vascular system using animals such as dogs, rabbits and rats, particularly:
-  mechanism of biomaterial interaction (e.g. PEU, PLL, PU, carbon fiber) with the tissues/fluids of the body, and effects
  of the tissue reactivity on changes in permeability, electrical, optical and mechanical properties of the novel artificial
  materials used for reconstruction.

(5.) ETHICAL ISSUES OF USING ANIMALS for:
a.)         Medical clinical, applied, and/or basic research;
b.)         Teaching in medical, veterinary and other biologically oriented schools/universities;
c.)         In a clinical veterinary setting and its application for human and animals benefit;
d.)         Education of the new generation of physician/veterinarian scientists/researchers and/or biologists in medical
             and/or veterinary and other related disciplines.


PROFESSIONAL EXPERIENCE:

(1.) GENERAL CLINICAL VETERINARY PRACTICE:
In Poland (Warsaw), in Holland, at M.A. van Messel and J.D.Th. Straatman’s Small Animal Hospital in Groningen, and
in
Canada, Guelph, Ontario (at Dr. Robert Butler’s Guelph Animal Hospital), in the veterinary clinical small animal
practice (mainly dogs and cats), including:
 a)
Surgery, such as ovariectomy, ovariohysterectomy, testectomy, prostatectomy, mastectomy, penile amputation,
     enterectomy, subcutaneous or pinna hematoma, gastric torsion, bone fracture, patellar reposition, hip dysplasia,
     extirpation of anal glands, lumpectomies, etc.;
b)
Radiology of hips, long bone fractures, abdomen and thorax cavities using digital radiography ;
c)
Dental surgeries and dental preventive medicine;
d)
Anesthesia: (1) sedation with e.g. meperidine or ketamine, acepromazine, atropine; (2) induction with e.g.
    thiopental, (3) surgical anesthesia with isoflurane/halothane and oxygen and (4) pre-/post-operative animal care;
e)
Treatment of diseases such as skin allergies due to external/internal parasites or food, otitis external, endometritis,
    Vit. D deficiency, prevention of heat and pregnancy in bitches, false pregnancy, parvovirus infections, diabetes,
    kidney and liver diseases, etc.;
f)
Vaccination of dogs for hepatitis, adeno type 2, parainfluenza, leptospirosis, parvovirus, rabies and cats with
   felocell, felocine, felocell RC, felocell CVR, FelV, rabies.

(2.) ORGAN TRANSPLANTATION in CLINICAL and COMPARATIVE MEDICINE:
In Poland (Polish Academy of Sciences, Warsaw), in Kuwait (University of Kuwait, Kuwait City) and in Canada
(University of Guelph, Ontario Veterinary College and currently at The Cambridge Center for Medical & Veterinary
Sciences Inc., in Guelph, Ontario):
 (a) participating in Human Organ Transplant Program(s) as a second assistant in the surgeries to obtain kidneys from
      living related donors or from cadaver donors, kidney procurement and storage, and during their transplantation into
      human recipients;
 (b) research and surgery (including microsurgery) training in the area of small animals (dog, swine, monkey, rabbit, rat,
       and mouse) soft tissue surgery (liver, lung, heart, spleen, skin) and vascular surgery involving kidney, liver, pancreas,
       ileum, lymph node auto-, allo-, xeno-transplantation, using various immunosuppressive protocols to prolong
      xenograft and/or allograft functional survival (including more than 250 kidney auto/allo-transplantation in dogs);
 (c) performing lymphography, angiography, urography, inulin renal function test, and the measurement of changes in total
      tissue water concentration in various organs.
 (d) microsurgery - collecting of the rat pancreas for preservation and transplantation using operating microscope (see
      Appendix II).
 (e) investigating the influence of various aspects of organ procurement on pre- and post-transplant organ viability,
      involving pancreas (monkey and rats), liver (dog-to-dog) or islet of Langerhans ( monkeys, pigs and rats) allo
      -transplantation.
 (f) evaluating of commonly used organ preservation solutions on abrogation of tissue edema and suppression of tissue
      autolysis following 96 hrs cold storage of rat/dog/pig pancreas/kidney (including solution's pH, osmolarity, oncotic
      pressure, -COOH group, free radical scavengers, and low/high molecular weight of selected ingredients of cold
      storage solutions, perfusion pressure, donor fasted vs. non-fasted, etc.);
 (g) reassessing the effect of kidney collection, storage and transplantation on organ function post-transplantation using a
       pig auto-transplantation protocol following UNOS standards;
 (h) reassessing pig kidney hyper-acute rejection following transplantation into the laboratory beagle dog with and without
       natural anti-pig antibody depletion by extracorporeal circulation of the recipient's blood through the donor pig's liver;
 (i) successfully creating, in utero, a 50% pig/dog chimera (assessed by DNA flow cytometric analysis based on DNA
      content) by the injection of dog bone marrow cells into the abdomen of the fetal pigs; (e) development of surgically
      -induced endometriosis in a mouse model, etc.;
 (j) currently establishing, implementing and promoting at
The Cambridge Center for Medical & Veterinary Sciences
      Inc
. (CMVS) clinical, teaching, research and diagnostic programs in the field of small animal (dogs and cats) medicine,
      small animal surgery, and small animal organ and tissue transplantation (in comparative studies with a human being)
      which planned to be expanded by a construction (in GTA) of 280,000-square-foot facility, a 7-level building (that
      includes 4 underground levels and 3 levels above the ground, to be build in accordance with the human hospital's
      standards and specifications) named here as a
Hospital (teaching- learning General Hospital) in a number of stages
      and sub-stages. For more information, please refer to the company's
Phase One and Phase 2 of this project.

(3.) TEACHING:
- Supervising and teaching senior, junior and technical staff the scientific methodology used in biological experiments,
  surgical and microsurgical techniques on animals, and animal care before and after operation, in agreement with Canadian
  Council on Animal Care (guide to the Care and Use of Experimental Animal, Vol. 1 & 2) and Animals for Research Act,
  Ontario, 1983;
- Seminars / lectures for 4th year students and senior/junior technical staff on the subject of organ transplantation and
   transplantation related immunology - "Elective in Veterinary Clinical Immunology" course (Canada);
- Seminars/lectures for under-graduate students on the subject of surgery (type of incisions, anatomy of abdominal wall,
   wound healing, tissue trauma/ischemia, surgical infections, shock, trauma, metabolism and the role of endocrine and
   immune systems in surgery, hemeostasis, etc.) including pre-operative preparation and post-operative management of
   surgical patients (Canada).
- Preparation of under-graduate and graduate students for their oral presentations or written assignments on subjects
   related to organ transplantation and/or general surgery (Canada).

(4.) SEMINARS / LECTURERS given for UNDER/GRADUATE and POST-GRADUATE courses:
- Human Living Organ Donors - Source of the Perfect Organ: The Risk;
- Transplantation Tolerance;
- Transplantation and the Religious Believes;
- Diagnosis of Rejection vs. Infection and Drug Toxicity;
- Clinical Organ Transplantation in Companion Animals;
- Treatment of Allo-Graft Rejection;
- Diet in Organ Transplant Recipients;
- Organ Transplantation (Medical Research) and Animal Rights Activists;
- Ethical Issues of Using Animals for Medical Research

(5.) ADMINISTRATION:
1. Organizing work at the operation theater and at the small animal (dog) farm. (at the Department of Experimental Surgery
     and Transplantation, Medical Research Center, Faculty of Medicine, Polish Academy of Sciences, Warsaw, Poland,
     1975-1983).
2. Supervising redistribution of incoming and outgoing pharmaceuticals for the small animals such as dogs, pigs, rabbits,
     monkeys and rats (at the Department of Experimental Surgery and Transplantation, Medical Research Center, Faculty of
     Medicine, Polish Academy of Sciences, Warsaw, Poland, 1975-1983).
3. Appointed to Associate Professor Position at t the Department of Experimental Surgery and Transplantation, Medical
     Research Center, Faculty of Medicine, Polish Academy of Sciences, Warsaw, Poland, 1980-1984.
4. Acting Chairman in the absence of the departmental chairman (on a few occasions in Poland and Kuwait).
5. Organizing the departmental research seminars (Poland, Kuwait).
6. Organizing Microsurgical Laboratory at the Ontario Veterinary College (at the Department of Clinical Studies, Ontario
     Veterinary College, OVC, University of Guelph, Guelph, Ontario, Canada, 1990-1997).
7. Evaluation of surgical procedures on behalf of the Animal Care Committee, University of Guelph, Ontario (Canada, 1995).
8. Writing Manual for the CCCM’s Faculty & Staff Position Interview(s), Guelph, ON (Canada, 1997).
9. Establishing and writing the Guidelines for the CCCM’s Ethics Committee for The Center for Clinical & Comparative
     Medicine (internal use) Guelph, Ontario (Canada, 1997-1998).
10. Establishing
The Cambridge Center for Medical & Veterinary Sciences Inc. – (Dr. M.P. Ruka, Founder & Owner)
    for the purpose of raising US$16.5 million to build according to the human hospital’s specifications in
Greater Toronto
    Area (GTA) a teaching-learning 300,000-square-feet General Hospital - Small Animal Hospital (name still to be
    decided in accordance with the College of Veterinarians of Ontario regulations), where the  clinical, teaching, research
    with diagnostic labs and services programs to assess the strategies to be undertaken by professionals in their fields of
    expertise (veterinary, human medicine, biology, etc.) in organ/tissue/stem cells transplantation/regeneration, oncology,
    and genome for the public health - the benefit of humans and animals - will be carried out - see
PHASE ONE and
    
PHASE 2 (Canada, From November 1998 – to present).
11. Dr. Ruka is Chairperson of the CMVS Board of Directors, First Director, and the President & Secretary at The
    Cambridge Center for Medical &Veterinary Sciences Inc. (CMVS) (Canada, 1998-to present).
12. Dr Ruka is holding a Faculty position of Professor Veterinary Surgery at The Cambridge Center for Medical
    & Veterinary Sciences Inc. (CMVS) (Canada, 2007-to present).
13. Writing The CMVS Manual of Organ/Tissue Transplantation for Humans and Animals Benefit – Development, Programs
    & Regulations (Canada, 1999 - to present).
14. Writing, preparing and completing the Handbook for the CMVS' Programs Investor (Business Plan) and its version for
    the Canadian Government, as well (with 10 Chapters, Canada 2000-2001).
15. Designing, writing, preparing and up-dating The Cambridge Center for Medical &Veterinary Sciences Inc. (CMVS)
    web page - http://www.CCMVS.com (Canada, 2004 – to present).
16. Establishing on-line an-open
International Clinical & Comparative Medical & Veterinary Sciences Journal – (Dr.
    M.P. Ruka, Founder & Owner, Publisher) providing an
instant publishing system (in less than 24 hours) for the
    professional colleagues around the World, the authors' of manuscripts presenting their various clinical, teaching, applied
    research ideas, new concepts, techniques, point of views and/or novel methods of treatment which are published without
    any delay(s), and for the purpose of securing and preserving the author's intellectual rights, as well. Journal’s web page:
    http://www.CCMVSJOURMAL.com (Canada, 2007-to present).


RESEARCH PROJECTS FUNDED:

1986-1987        The effect of isoosmolar, hyperosmolar and hyperoncotic solutions on rat pancreas stored at 4°C
                    for up to 96 hrs
(Principal investigator, grant from the University of Kuwait in the amount of C$4,400.00).
1990-1992       
 The effect of in vivo flushing and simple cold (4°C) preservation in UW Belzer solution on the wet
                   weight and morphology of the rat/dog pancreas and pig/dog kidney
.  (Principal investigator, grant from
                   the Department of Clinical Studies, OVC, University of Guelph, Guelph, Ontario, Canada in the amount of
                   C$5,000.00).
1990-1992       
 The effect of flush-preservation solution with or without free radical inhibitors on the change in the
                   wet weight and morphology of rat pancreas exposed to cold ischemia (4°C) for a period of 96 hours
                   (Principal investigator, grant from the Department of Clinical Studies, OVC, University of Guelph, Guelph,
                   Ontario, Canada in the amount of C$5,000.00).
1991-1993       
Use of (31P)-MRS and MRI (1H) to assess pre- and post-transplantation pig and dog kidney viability
                   (Principal investigator, cooperation with Dr. E. Janzen, MRI Facility).
1992-1993       
 Guyton's sphere in rat treated with CCl4 (cooperation with Dr. E. Janzen, principal investigator).
1993-1995        
A pilot project to test the hypothesis that it is feasible to modify the kidney of a pig to make it more
                   acceptable immunologically when transplanted into a dog.
(Principal investigator, grant from the
                   Ontario Veterinary College and the Department of Clinical Studies, OVC, University of Guelph, Guelph,
                   Ontario, Canada in the amount of C$13,000.00).
1994-1995      
  Development of a rodent model for investigations of the pathophysiology of endometrosis:
                   Applications of MRI/MRS in the assessment of endometriotic lesions
(cooperation with Dr. E. Janzen,
                   Guelph, Ontario and Dr. W. Foster, Ottawa, Ontario, principal investigators).



INVITED as GUST SPEAKER  to deliver SEMINARS / COURSES / LECTURES:

1981        -        from Dr. N.L. Tilney, Professor of Surgery, Surgical Research Laboratory, Harvard Medical School,
                   Boston, MA (7 days).
1983        -        from Prof. Dr. V. Bartos, Department of Experimental Surgery, Czechoslovak Academy of Sciences,
                   Prague, Czechoslovakia (4 weeks).
1986        -        from Dr. J. Gajentaan, Professor of Medicine, Department of Small Animal Surgery, Faculty of Veterinary
                   Medicine, University of Utrecht, Holland (3 days).
1987        -        from Dr. J. Gajentaan to deliver a lecture at the XXIII World Veterinary Congress (Small Animal
                   Veterinary Association), Montreal, Canada (6 days), entitled:
Current problems of the oesophagus
                   reconstruction: clinical and experimental studies.
1990        -        from Dr. R. Guidoin, Professor of Surgery, Experimental Surgery Laboratory, Pavillon de Services,
                   Faculty of Medicine, Laval University, Quebec City, January 15th, (1 day), to deliver a lecture entitled:
The
                   pancreas preservation: past, present, and future.
1990        -        From Dr. D.G. Butler, Professor of Veterinary Medicine, Department of Clinical Studies, Ontario
                   Veterinary College, University of Guelph, Ontario, Canada, February 14, (2 days).
1992        -        from Dr. A. Kaushik and Dr. P. Shewen to deliver two lectures for the seminar in the "Elective in
                   Veterinary Clinical Immunology" course at the Ontario Veterinary College, University of Guelph, Guelph,
                   Ontario, on November 2 and 6, 1992, for 4th year students, entitled:
                    1.  
The Effect of HLA Tissue Typing, ABO Blood Group Matching and Blood Transfusion on
                         Cadaver (CD), Living Related (LRD) and Living Non-Related Donor (LN-RD) Graft Survival in
                         Recipient With Immunosuppression.
                   2.   Introduction to the Xenograft Transplantation Program at the University of Guelph.
1993        -        From Dr. D. Benn, the Central Animal Facility, OVC, University of Guelph, Guelph, Ontario, April 29,
                   1993, to deliver a seminar entitled:
Introduction to organ transplantation for the benefit of human
                   medicine and the benefit of companion animals (dog/cat).
1993        -        From Dr. D. Benn, the Central Animal Facility, OVC, University of Guelph, Guelph, Ontario, November
                   25, 1993, to deliver a seminar entitled:
Kidney xenograft transplantation for the benefit of human and
                   veterinary medicine.
1994        -        From Drs. A. Kaushik and P. Shewen to deliver a lecture for two seminars in the "Elective in Veterinary
                   Clinical Immunology" course, at the Ontario Veterinary College, University of Guelph, Guelph, Ontario,
                   organized on February 1 and March 8, 1994, for 4th year students, entitled:
The effect of MHC Class I
                   and Class II antigens, ABO blood group matching and blood transfusion on cadaver (CD), living
                   related donor (LRD) and living non-related donor (LN-RD) graft survival in recipient with
                   immunosuppression
.
1994        -        From Dr. David H. Sachs, Professor of Surgery and Director, Transplantation Biology Research Centre,
                   Harvard Medical School, Massachusetts General Hospital, Boston, MA, and Dr. A. Benedict Cosimi,
                   Professor of Surgery Transplantation Unit, Massachusetts General Hospital, Boston, MA, April 22, 1994,
                   to deliver a seminar entitled:
Xenotransplantation: Pig kidney to dog.
1994        -        From Dr. Jimmy A. Light, Professor of Surgery, Director, Transplantation Services, Washington Hospital
                   Centre, Washington, DC, May 4, 1994, to deliver a seminar entitled:
Organ preservation: Factors
                   influencing tissue resistance to cold ischemic injury.
1994        -        From Dr. D. Benn, the Central Animal Facility, Ontario Veterinary College, University of Guelph, Guelph,
                   Ontario, October 20, 1994, to deliver a seminar entitled:
Mechanism of Tissue Rejection in Allo- and
                   Xeno- Grafts Post Transplantation.
1995        -        From Drs. A. Kaushik and P. Shewen to deliver a lecture for two seminars in the "Elective in Veterinary
                   Clinical Immunology" course, at the Ontario Veterinary College, University of Guelph, Guelph, Ontario,
                   organized on February 7 and March 14, 1995, for 4th year students, entitled:
The effect of MHC Class I
                   and Class II antigens, ABO blood group matching and blood transfusion on cadaver (CD), living
                   related donor (LRD) and living non-related donor (LN-RD) graft survival in recipient with
                   immunosuppression.
1995        -        From Dr. Denna Benn, Director, the Animal Care Services, at the University of Guelph, Guelph, Ontario,
                   October 16, 1995, to deliver lectures at the seminar entitled:
Surgical techniques for under-graduate
                   students, as an integral part of the course (73-260, Fall 1995) "Introduction to Laboratory Animal Care and
                   Management".
1997        -        From Dr. Allan S. MacDonald (Professor of Surgery and Transplantation, Director of Transplant
                   Programs & Services) to visit Dalhousie University/QE II Health Science Centre, and to initiate scientific
                   cooperation between both our Centers in the medical/veterinary field of organ transplantation, on June 27,
                   1997.


PRIZES AND GRANTS:

1976        -        The Scientific Personnel Commission of the Scientific Council in the Centre of Experimental and Clinical
                     Medicine of the Polish Academy of Sciences, Warsaw, Poland, supported a doctorate grant for the period
                     from April 1, 1976 to March 31, 1977.
          SUBJECT:
"The effect of hyperosmolar solutions on the metabolism of liver cells".

1984        -        Dutch post-doctoral fellowship at the Department of Experimental Surgery and Central Animal Laboratory,
                    Medical Faculty, University of Groningen, Holland, for the period from January 1, 1984 to Jan. 31, 1985.
          SUBJECT:
"Bio-compatibility of biodegradable and non-biodegradable grafts implanted into trachea and
                              oesophagus".

1990        -        Canadian post-doctoral fellowship at the Department of Clinical Studies, Ontario Veterinary College,
                    University of Guelph, Guelph, Ontario, Canada, for the period from June 18, 1990 to June 18, 1991.
          SUBJECT:
"Post/Flushing and Post/Ischemic Tissue Reperfusion Injury".

1991        -        The Winner of the President's Award for the best abstract in the Biological Section of the 18th Annual
                     Meeting of the Microscopical Society of Canada in Calgary, Alberta, Canada, June 23-26
                     entitled:
"Light and electron microscopic assessment of autolysis of rat and dog pancreas stored at
                                  4°C for up to 96 hours: The effects of fasting organ donors pre-operation, tissue
                                  dehydration during preservation and using low pH of flushing/preservation solutions".


PAPERS PRESENTED at the CONGRESSES:

Please refer to Appendix I. pp. 14-18


POSTGRADUATE COURSES & MEETINGS ATTENDED:

Please refer to Appendix III. pp. 21-22


MISCELLANEOUS:

1. Ruka MP. Impact of hyperosmolar and hyperoncotic solutions on water distribution in organs to be
                   transplanted.
Ph.D. Thesis, 1980.

2. Ruka MP.
The effect of isoosmolar, hyperosmolar and hyperoncotic solutions on rat pancreas storage at 4°C
                    for up to 96 hours.
 RIG: University of Kuwait, Project No. MDT-177 (final report), 1987.

3. Ruka MP, Gareau P, Foster RA, Foster WG, Janzen EG.
Development of a Rodent Model for Investigations of
   the Pathophysiology of Endometriosis: Application of MRI/MRS in the Assessment of Endometriotic Lesions
   
(Contract Ref. No. 4622; Project No. K331219). Final report prepared for Dr. Warren G. Foster (Principal
   Investigator, Head, Reproductive Toxicology Section, Environmental Health Directorate, Health Canada, Ottawa,
   Ontario K1A 0L2), March 1995.


ACKNOWLEDGEMENTS:

1.  "Effect of Major Transfusions of Electrolytes, Glucose, and Dextran on the Pressure of Intraparenchymatous
    Liquid in the Lung Tissue"
. Department of Experimental Surgery, Centre of Experimental and Clinical Medicine of
    the Polish Academy of Sciences, Warsaw, Poland. (Principal investigator - Dr. A. Deszkiewicz). Thesis for a Ph.D.
    degree completed in 1976.

2.  
"Effect of Major Transfusions of Conserved Blood on the Respiratory System". Centre of Experimental and
    Clinical Medicine, Polish Academy of Sciences, Warsaw, Poland, Department of Experimental Surgery and
    Transplantation. (Principal investigator - Dr. J. Czajkowski). Thesis for a Ph.D. degree completed in 1976.

3.  
"Immunological Characteristics of Pre-lymph Node Cells". Department of Experimental Surgery and
    Transplantation, Centre of Experimental and Clinical Medicine of the Polish Academy of Sciences, Warsaw, Poland.
    (Principal investigator - Dr. H. Galkowska). Thesis for a Ph.D. degree completed in 1980.

4.  
"The level of Digoxin in Tissue and Body Fluids in Experimental Conditions and in the Course of
    Hypokalemia".
The Clinic of Angiopathy, Institute of Internal Diseases, Medical Academy of Warsaw, Poland.
    (Principal investigator - Dr. W. Grzesiuk). Thesis for a Ph.D. degree completed in 1981.


MEMBERSHIP IN PROFESSIONAL ASSOCIATIONS:

-        International Society of Lymphology,                 since 1980
-        Polish Society of Surgery,                                      since 1983
-        Society for Organ Sharing,                                     since 1988
-        Microscopical Society of Canada,                       since 1990
-        Canadian Transplantation Society,                      since 1993
-        American Society of Transplantation - since 1998 (formerly the American Society of Transplant Physicians,
    formed in 1982)                                                       since 1995
-        College of Veterinarians of Ontario (CVO)         since 1995
-        Xenotransplant Association                                    since 1998


PUBLICATIONS:

Please refer to Appendix I. pp. 9-13

Published 83 publications:
- Original papers - 23 (8 as a first author)
- Conference Presentations and Published Abstracts - 60 (39 as a first author)


                                                      APPENDIX I

LIST OF ORIGINAL ARTICLES
(Published in Scientific and Clinical Journals):

1.      Czajkowski J, Deszkiewicz A, Polanski J, Ruka M, Olszewski W.  Anaesthesia for ortotopic allogenic liver
transplantation in Pigs
/in Polish/.  Anest Reanim Intens Terap 1976; 8(3): 317-327.
2.      
Ruka M, Plachta J, Kupiec-Weglinski J, Olszewski W.  Technique for long period cannulation of hepatic and portal
veins in dogs
/in Polish/.  Pamietnik 48 Zjazdu Towarzystwa Chirurgow Polskich 1976, p. 573.
3.      
Ruka M, Plachta J, Olszewski W.  Extracorporeal hemoperfusion through an activated charcoal column /in
Polish/.  Pamietnik 48 Zjazdu Towarzystwa Chirurgow Polskich 1976, p. 466-7.
4.      Lukasiewicz H, Olszewski W,
Ruka M.  Pharmacological prolongation of the hyperacutely rejected xenografts /in
Polish/.  Pamietnik 48 Zjazdu Towarzystwa Chirurgow Polskich 1976, p. 565-6.
5.      Olszewski W, Lukasiewicz H, Kossakowski A, Galkowska H,
Ruka M.  Inhibition of leukocyte migration by serum
effluent from hyperacutely rejected xenografts.
 Transplantation 1976; 22(5): 526-528.
6.      Dabrowska B,
Ruka M, Walczak E.  The electrocardiographic diagnosis of left septal fascicular block.  Eur J
Cardiol 1978; 6(5): 347-357.
7.      
Ruka MP, Olszewski WL.  Lack of protective effects of hypertonic mannitol on ischemic kidney in dog.  Acta
Med Pol 1978; 19(1-2): 53-57.
8.      Plachta N, Rowinski W, Ryffa T,
Ruka M, Stepkowski S.  Correlation of in vitro viability assays with the life
supporting function of the ischemically damaged kidney.  
Acta Med Pol 1978; 19(1-2): 35-42.
9.      Rowinski W, Ryffa T, Stepkowski S, Wozniewicz B,
Ruka M, Wasowaska B, Hay M, Olszewski W. Active
enhancement of dog kidney allografts using ALG and donor platelets.
 Arch Immunol Therap Exp 1978; 26: 1013
-1019.
10.    Olszewski W, Stefanska E, Ruka M, Lukasiewicz H.  
Biological and biochemical characteristics of serum fraction
effluent from xenografts and inhibiting leukocyte migration.
 Arch Immunol Therap Exp 1978; 26: 1083-1086.
11.    Olszewski WL, Lukasiewicz H, Stefanska A, Wachal T,
Ruka M.  Immune complexes in serum of the hyperacutely
rejected xenografts.
 Transplantation Proceedings, 1979; 11(2): 1410.
12.    Olszewski WL,
Ruka M.  The effect of osmolality of washout solution.  Organ Preservation, III Ed., D.E. Pegg,
1979, pp 124-131.
13.    Rowinski W, Ryffa T, Stepkowski S,
Ruka M, Wasowska B, Galkowska H.  Prolongation of allogenic kidney graft
survival using antilymphocyte globulin and donor antigen
/in Polish/.  Pol Przegl Chir 1980; 7a: 348-349.
14.    
Ruka MP, Olszewski WL.  The effect of hyperosmolar solutions on thoracic duct lymph flow. Progress in
Lymphology, Avicenum Czechoslovak Medical Press, Prague, 1981, pp 133-135.
15.    Rowinski W, Ryffa T,
Ruka M, Wasowska B, Tilney NL, Olszewski WL.  Platelet - induced donor specific
unresponsiveness to kidney allografts in mongrel dogs treated with ALG
.  Transplantation Proceedings 1981; 13(1):
586-588.
16.    Szczepanska-Sadowska E, Ruka M, Sobocinska J, Kozlowski S.  
Suppression of thirst in dogs with arteriovenous
fistula
.  Arch Internat Physiol Biochim 1981; 89: 269-273.
17.    
Ruka M, Olszewski WL.  The influence of diuretics on lymph flow and composition from lymphoedematous
tissues
.  Progress in Lymphology, Avicenum Czechoslovak Medical Press, Prague, 1982, pp 487-492.
18.    Wachal T, Olszewski WL,
Ruka M.  Hyperacute rejection of xenografts. I.  Arch Immunol Therap Exp 1983; 31:
231-235.
19.    Wachal T, Olszewski WL,
Ruka M.  Hyperacute rejection of xenografts. II.  Arch Immunol Therap Exp 1983; 31:
273-281.
20.    Rowinski W,
Ruka M, Stuart F, Buckingham F.  Amelioration of the ischemic damage of the dog kidney subjected
to 90 minutes of warm ischemia by lidocaine pretreatment and low-dose dopamine infusion on revascularization
.
Advances in Experimental Medicine and Biology, 1987; 212: 291-297.
21.    
Ruka MP, White AG, Kumar MSA, Al-Abdullah IH, Abouna GM.  Change in the weight of pancreas during
preservation in various solutions
. Transplantation Proceedings, 1989; 21(1): 1372-1375.
22.    
Ruka MP, Tungekar MF, Kuit J, Hofstra W.  A partial replacement of the oesophageal muscle layers by carbon
-fibre prosthesis
.  Eur Surg Res 1991; 23(1): 35-45.
23.    Foster, W.G.,
Ruka, M.P., Gareau P., Foster R.A., Janzen E.G., and Yang J.Z. Morphologic characteristics of
endometriosis in the mouse model: application to toxicology
. Canadian Journal of Physiology and Pharmacology,
1997; 75: 1188-1196.


LIST OF CONFERENCE PRESENTATIONS (ORAL AND POSTER SESSIONS) AND PUBLISHED
ABSTRACTS
in Scientific and Clinical JOURNALS:

1.      Ruka M, Plachta J, Olszewski WL. Extracorporeal hemoperfusion through an activated charcoal column /in
Polish/. 48th Congress of the Polish Surgical Society, Warsaw, 1976, Abstracts, p.180.
2.      Olszewski W,
Ruka MP. Hyperosmolality as effector preventing ischemic changes in kidneys.  International
Symposium on Preservation and Storage of Organ and Tissues for Transplantation, Warsaw, 1977.
3.      Benendo-Kapuscinska B,
Ruka M. Experimental obstruction of ileum in dogs /in Polish/. 28th Congress of Polish
Radiological Society, Wroclaw 1977, Abstracts, p 29.
4.      Plachta N, Ryffa T,
Ruka M, Rowinski W. A correlation of in vitro tissue viability assays with life-supporting
function of ischemically damaged kidney
. 12th Congress of the European Society for Surgical Research, Warsaw,
Abstracts, Eur surg Res 1977; 9(1): 81.
5.      Rowinski W, Ryffa T, Stepkowski S,
Ruka M, Wasowska B, Galkowska H. Prolongation of allogenic kidney graft
survival using antilymphocyte globulin and donor antigen
/in Polish/. 49th Congress of the Polish Surgical Society,
Torun, 1978.
6.      Rowinski W, Ryffa T, Stepkowski S,
Ruka M, Wasowska B, Galkowska H. Enhancing effect of donor platelets on
kidney allograft survival in the unmatched mongrel dogs pretreated with ALG
. XV Congress of the European
Dialysis and Transplant Association, Istanbul, 1978, Abstracts, p.196.
7.      Rowinski W, Ryffa T, Stepkowski S,
Ruka M, Wasowska B, Galkowska, Olszewski W.  Active enhancement of dog
kidney allograft using ALG and donor platelets
. 13th Congress of the European Society for Surgical Research,
Helsinki, Abstracts, Eur surg Res 1978; 10(1): 8-9.
8.      Olszewki WL, Lukasiewicz H, Wachal B,
Ruka M. Immune complexes in the serum of hyperacutely rejected
xenografts
. Congress of the International Transplantation Society, Rome, 1978.
9.      Olszewski WL,
Ruka M. The effect of osmolality of wash-out solutions.  Symposium of Organ Transplantation,
Odensee, Denmark, April, 1978.
10.    
Ruka M, Olszewski WL. The effect of hyperosmolar solutions on thoracic duct lymph flow.  Congress of Surgical
Research, Zakopane, 1979, Abstracts, p 111.
11.    Rowinski W, Ryffa T,
Ruka M, Plachta N, Stepkowski S, Olszewski W. The use of specific and nonspecific
immunosuppression for prolongation of dog kidney allograft survival
.  Congress of Surgical Research, Zakopane,
1979, Abstracts, p 96.
12.    
Ruka M, Olszewski WL. The effect of hyperosmolar solutions on thoracic duct lymph flow.  7th International
Congress of Lymphology, Florence, 1979, Abstract, p 58.
13.    Grzesiuk W,
Ruka M, Preibisz J. Digoxine level in tissues and body fluids in hypokalemia: experimental studies /in
Polish/. 3rd Congress of Polish Cardiological Society, Poznan, 1979, Abstracts, p 75.
14.    Bilenko MB, Olszewski WL, Rowinski W,
Ruka M, Murawska M, Lukomska B. Rabbit kidney xenograft in dogs as
a hyperacute rejection model.
 7th International Congress of Organs Transplantation, Baku, 1979.
15.    Kozlowski S,
Ruka M, Szczepanska-Sadowska E, Sobocinska J. Enhancement of osmotic thirst in dogs with
arteriovenous fistulae
. 7th International Conference on the Physiology of Food and Fluid Intake, Warsaw, 1980,
Abstracts, p 45.
16.    
Ruka MP, Olszewski WL.  The effect of postoperative infusion of hyperosmolar and hyperoncotic solutions on
mobilization of water from the traumatized tissues
. 15th Congress of the European Society for Surgical Research,
Brussels, Abstracts, Eur surg Res 1980; 12: 47-48.
17.    Rowinski W, Ryffa T,
Ruka M. Platelets induced donor specific unresponsiveness to allogenic kidney in mongrel
dogs treated with ALG
.  VIII International Congress of the Transplantation Society, Boston, 1980.
18.    
Ruka M. Whole body distribution of hyperosmotic and hyperoncotic solutions used as protectors in donors'
organs
.  IV Symposium fur Experimentelle Urologie, Rostock-Warnemunde, 1981.
19.    
Ruka M, Olszewski WL. The influence of diuretics on lymph flow and composition from lymphoedematous
tissues
. 8th International Congress of Lymphology, Montreal 1981, Abstract p 44.
20.    
Ruka M, Olszewski WL. Influence of hyperoncotic fluid infusion on wound water content.  8th Quadrilateral
Congress of Experimental Surgery, Budapest, 1981, Abstracts, p 38.
21.    
Ruka M. Kunstliche Drainage im Ductus thoracicus. (in English). V Symposium uber Experimentelle Urologie,
Rostock-Warnemunde, 1983.
22.    
Ruka M, Przeor A, Olszewski W. Permeability of lymph vessels and nodes. Hungarian Experimental Surgical
Congress, Debrecen, 1983, Abstracts, p 33.
23.    
Ruka M, Olszewski W. Influence of hyperosmolar fluids on wound water content (in Polish).  51st Congress of the
Polish Society of Surgery, Lodz, Poland, 1983, Proceedings pp 338-347.
24.    
Ruka M, Przeor A, Olszewski W. Permeability of lymph vessels to proteins. 9th Congress of Lymphology, Israel,
1983, Abstracts, p 86.
25.    
Ruka M, Rowinski WA, Plachta S, Morzycka M, Smogorzewski M. Lignocaine pretreatment and constant
dopamine infusion protects dog kidney against ischemic damage
. 19th Congress of the European Society for
Surgical Research, Zurich, Abstracts, Eur surg Res 1984; 16(1): 76.
26.    
Ruka M, Rowinski WA, Lipski M, Wasiutynski A, Olszewski W. Expanded P.T.F.E. Grafts in restoring bile
drainage in dogs
. 20th Congress of the European Society for Surgical Research, Rotterdam, Abstracts, Eur Surg Res
1985; 17(1): 77-78.
27.    
Ruka MP, Kuit J, Hofstra W, Tungekar F, Wildevuur ChRM, Koers R, Heikamp A.  Total Reconstruction of the
Rabbit Trachea by Implanted a Poly-Ether-Urethane Prosthesis
. International Symposium on Biotechnology in
Clinical Medicine, Rome, 1987, Abstracts, p 231.
28.    
Ruka MP, Kuit J, Hostra W, Tungekar F, Wildevuur ChRM, Koers R, Heikamp A.  A Carbon-Fiber Material as a
Functional Adequacy of Oesophageal Muscle Layer
.  International Symposium on Biotechnology in Clinical Medicine,
Rome, 1987, Abstracts, p 230.
29.    
Ruka MP, Kuit J, Tungekar F, Wildevuur ChRM. The Oesophageal Muscle Layer Reconstruction by Implanted a
Carbon-Fiber Prosthesis
.  XXIII World Veterinary Congress, Montreal, 1987, Abstracts, p 192.  (Invited lecture)
30.    
Ruka MP, Kuit J, Hofstra W, Tungekar MF, Wildevuur ChRM. A partial replacement of the rabbit trachea by
implantation of a poly-ether-urethane (P.E.U.) prosthesis
. International Society for Artificial Organ, Abstracts,
Rostock - Warnemunde, 1987.
31.    
Ruka MP, Kumar MSA, White AG, Abouna GM. The effect of isoosmolar, hyperosmolar and hyperoncotic
preservation solutions on rat pancreas stored at 4 degrees C for up to 96 hours
. First International Congress on
Pancreatic and Islet Transplantation, Stockholm, Sweden, 1988, Abstracts, p 94; Diabetes 1989; 38(S1): 241.
32.    Al-Abdullah IH, Kumar MSA,
Ruka MP, Abouna GM. Isolation of rat pancreatic islets of Langerhans using
Trowell's TS medium
. First International Congress on Pancreatic and Islet Transplantation, Stockholm, Sweden, 1988,
Abstracts, p 149; Diabetes 1989; 38(S1): 273.
33.    Al-Abdullah IH, Kumar MSA,
Ruka MP, Abouna GM. Successful islets transplantation using cyclosporin in
outbred sprague-dawling rats
. XII International Congress of the Transplantation Society, Sydney, Australia, 1988,
Poster Abstract Book, p 90.
34.    
Ruka MP, Kumar MSA, White AG, Abouna GM. Changes in the wet weight of pancreas during preservation in
various solutions
. XII International Congress of the Transplantation Society, Sydney, Australia, 1988, Oral Abstract
Book, p 298  (Oral presentation)
35.    
Ruka MP, Mathews KA, Hulland TJ, Winter CA, Butler, DG. Light and electron microscopic assessment of
autolysis of rat and dog pancreas stored at 4°C for up to 96 hours. The effects of fasting organ donors pre
-operation, tissue dehydration during preservation and using low pH flushing/preservation solutions
. 18th Annual
Meeting of the Microscopical Society of Canada, Calgary, Alberta, Canada, Proceedings 1991; 18: 110-111. (Poster
presentation)
*  The Winner of the President's Award in Biological Section of MSC/SMC.
36.    
Ruka MP, Hulland TJ, Mathews KA, Winter CA, Butler DG. Suppressed autolysis of rat/dog pancreas during
simple long-term (96 hours) cold storage (4°C) in Belzer UW-CSS and Minnesota human pancreas perfusate
(Minn. HPP) solutions correlated with tissue dehydration
. The Royal College of Physicians and Surgeons of Canada,
the 60th Annual Meeting, and the Canadian Transplantation Society Annual Meeting, Quebec City, Quebec, Canada,
1991, Clinical and Investigative Medicine 1991; 14(4): A138-858. (Poster presentation)
37.    
Ruka MP, Mathews KA, Von Althen N, Butler DG. Rat and dog pancreas tissue-water loss (dehydration) in Belzer
UW-CSS and Euro-Collins solutions following long-term cold ischemia (4°C)
. The Royal College of Physicians and
Surgeons of Canada, the 60th Annual Meeting, and the Canadian Transplantation Society Annual Meeting, Quebec City,
Quebec, Canada, 1991, Clinical and Investigative Medicine 1991; 14(4): A138-859. (Poster presentation)
38.    Mathews KA, Ruka
MP, Hulland TJ, Butler DG. The effect of low or high pH flushing/preservation solutions
(Belzer UW-CSS and 0.9% NaCl) on rat pancreas stored at 4°C for up to 96 hours
. The Royal College of
Physicians and Surgeons of Canada, the 60th Annual Meeting, and the Canadian Transplantation Society Annual
Meeting, Quebec City, Quebec, Canada, 1991, Clinical and Investigative Medicine 1991; 14(4): A138-860. (Poster
presentation)
39.    Mathews KA,
Ruka MP, Hulland TJ, Black F, Butler DG. Evidence that fasting of donor rats adversely affects
pancreas tissue-water content during preservation by simple cold storage at 4°C for up to 96 hours
. The Royal
College of Physicians and Surgeons of Canada, the 60th Annual Meeting, and the Canadian Transplantation Society
Annual Meeting, Quebec City, Quebec, Canada, 1991, Clinical and Investigative Medicine 1991; 14(4): A138-861.
(Poster presentation)
40.    
Ruka MP, Hulland TJ, Mathews KA, Janzen EG, Butler DG. The effect of three cold storage solutions on rat and
dog pancreas and kidney tissue-water content and morphology
. The Royal College of Physicians and Surgeons of
Canada, the 61st Annual Meeting, and the Canadian Transplantation Society Annual Meeting, Ottawa, Ontario, Canada,
1992, Clinical and Investigative Medicine 1992; 15(4): A149-940. (Poster presentation)
41.    
Ruka MP, Hulland TJ, Mathews KA, Janzen EG, Butler DG. Suppression of tissue edema by potassium
lactobionate (PLA) correlates with suppression of tissue autolysis in long-term cold stored rat pancreas
. The
Royal College of Physicians and Surgeons of Canada, the 61st Annual Meeting, and the Canadian Transplantation
Society Annual Meeting, Ottawa, Ontario, Canada, 1992, Clinical and Investigative Medicine 1992; 15(4): A152-957.
(Poster presentation)
42.    Towner, RA,
Ruka MP, McCutcheon J, Butler DG, Janzen EG. Changes in ex vivo pre-transplantation tissue
PME/ß-ATP ratios in pig and dog kidney using 31P-MRS do not correlate with pre-transplantation tissue
morphology and tissue hydration status indicators of organ function post-transplantation
. 20th Annual Meeting of
the Microscopical Society of Canada, Toronto, Ontario, Canada, June 3-5, 1993. Proceedings 1993; 20: 170-171.
(Poster presentation)
43.    
Ruka MP, Hulland TJ, Mathews KA, Janzen EG, Butler DG. Selected factors conserve rat pancreas morphology
when organ exposed ex vivo to long-term cold ischemia
.  20th Annual Meeting of the Microscopical Society of
Canada, Toronto, Ontario, Canada, June 3-5, 1993. Proceedings 1993; 20: 158-159. (Poster presentation)
44.    
Ruka MP, Hulland TJ, Mathews KA, Janzen EG, Butler DG. Fasting donor rat and use of Belzer but not 0.9%
NaCl for flushing and storage enhances resistance to cold ischemic injury.
First Joint Conference of the Canadian
Transplantation Society and the Canadian Association of Transplantation, Whistler, British Columbia, Canada,
September 9-11, 1993, Abstracts p 32, Clinical and Investigative Medicine 1993; 16(4): B139-863.
(Poster presentation)
45.    Towner RA,
Ruka MP, McCutcheon J, Butler DG, Janzen EG. Use of (31P)-MRS for Pre-transplant assessment of
pig and dog kidney viability: No correlation with tissue PME/Pi or PME/ß-ATP ratios
.  First Joint Conference of
the Canadian Transplantation Society and the Canadian Association of Transplantation, Whistler, British Columbia,
Canada, September 9-11, 1993, Abstracts p 38, Clinical and Investigative Medicine 1993; 16(4): B140-864.
(Poster presentation)
46.    
Ruka MP, Mathews KA, Butler DG. Introduction to the University of Guelph Xenotransplantation Group. First
Joint Conference of the Canadian Transplantation Society and the Canadian Association of Transplantation, Whistler,
British Columbia, Canada, September 9-11, 1993, Abstracts p 38, Clinical and Investigative Medicine 1993; 16(4):
B140-865. (Poster presentation)
47.    Gareau PJ,
Ruka MP, Reinke LA, Butler DG, Janzen EG. The use of MRI and spin trapping to study CCL4-induced
hepatotoxicity in rats implanted with Guyton's sphere
. 4th International Symposium on Spin Trapping and Organic
EPR Spectroscopy with Applications in Chemistry, Biology and Medicine, Oklahoma City, Oklahoma, USA, October
24-28, 1993. Abstracts book. (Poster presentation)
48.    
Ruka MP, Butler DG, McCutcheon J, Mallard BA, Janzen E, Cockshutt J, Miller C, Plante C.  Xenotransplantation:
Pig kidney to dog
.  21st Annual Meeting of the Microscopical Society of Canada, Montreal, Quebec, Canada, June 12
-15, 1994. Proceedings 1994; 21: 60-61. (Oral presentation)
49.    
Ruka MP, Hulland TJ, Mathews KA, Butler DG.  Better preservation of the rat pancreas morphology in dextran
(MW 2,000,000) than in Belzer UW-CSS after 96 hrs of simple cold (4°C) storage
.  21st Annual Meeting of the
Microscopical Society of Canada, Montreal, Quebec, Canada, June 12-15, 1994.  Proceedings 1994; 21: 100-101.
(Oral presentation)
50.    
Ruka MP, Butler DG, Mallard BA, McCutcheon J, Janzen E, Cockshutt J, Miller C, Plante C.  Xenotransplantation:
Pig kidney to dog.
Strategies for Successful Xenotransplantation-IBC USA Conference, Washington, DC, USA, June
16-17, 1994. (Poster presentation)
51.    
Ruka MP, Mathews KA, Hulland TJ, McCutcheon J, Butler DG. The effect of tissue dehydration with dextran (MW
2,000,000) on suppression of tissue edema, and abrogration of tissue autolysis in long-term (96 hrs) cold stored
(4°C) rat pancreas
. 63rd Annual Meeting of The Royal College of Physicians and Surgeons of Canada, Canadian
Society of Nephrology, Toronto, Ontario, Canada, September 14-19, 1994, Clinical and Investigative Medicine 1994;
17(4): B99-584. (Poster presentation)
52.    
Ruka MP, McCutcheon JL, Butler DG. 50% decrease in hydrostatic pressure during initial flushing of rat
pancreas decreased tissue edema during short- and long-term cold (4°C) storage
.  64th Annual Meeting of The
Royal College of Physicians and Surgeons of Canada, Canadian Society of Nephrology, Montreal, Quebec, Canada,
September 13-17, 1995, Clinical and Investigative Medicine 1995; 18(4): B96-633. (Poster presentation)
53.    
Ruka MP, Hulland TJ, Janzen EG, Butler DG. Lack of protective effect of the -COOH group and the MW 307 of
glutathione
. 64th Annual Meeting of The Royal College of Physicians and Surgeons of Canada, Canadian Society of
Nephrology, Montreal, Quebec, Canada, September 13-17, 1995, Clinical and Investigative Medicine 1995; 18(4):
B96-634. (Poster presentation)
54.    
Ruka MP, McCutcheon JL, Gareau PJ, Foster WG, Janzen EG. Evaluation of estrogen/progesterone treatment on
the functional integrity of the endometrium temporally exposed to warm ischemia prior to its auto
-transplantation
. 64th Annual Meeting of The Royal College of Physicians and Surgeons of Canada, Canadian
Association of Pathologists, Montreal, Quebec, Canada, September 13-17, 1995, Clinical and Investigative Medicine
1995; 18(4): B11-723. (Oral presentation)
55.    
Ruka MP, McCutcheon JL, Gareau PJ, Foster WG, Janzen EG. Surgically induced model of endometriosis in
B6C3F1 mice
. 64th Annual Meeting of The Royal College of Physicians and Surgeons of Canada, Canadian Association
of Pathologists, Montreal, Quebec, Canada, September 13-17, 1995, Clinical and Investigative Medicine 1995; 18(4):
B11-723. (Poster presentation)
56.    
Ruka MP, Foster RA, Butler DG. 50% decrease in hydrostatic pressure during initial flushing of rat pancreas
significantly reduced tissue edema during short- and long-term cold (4°C) storage
. Joint Annual Meeting of the
Canadian Association of Transplantation and the Canadian Transplantation Society, Montreal, Quebec, Canada,
September 13-17, 1995. Scientific Abstract Book p 41, abstract no. 30. (poster presentation)
57.    
Ruka MP, Hulland TJ, Janzen EG, Butler DG. Involvement of the receptor but not the -COOH group or the MW of
potassium lactobionate in long-term (96-hrs) cold stored (4°C) rat pancreas
. Joint Annual Meeting of the Canadian
Association of Transplantation and the Canadian Transplantation Society, Montreal, Quebec, Canada, September 13
-17, 1995. Scientific Abstract Book, p 45, abstract no. 40. (Poster presentation)
58.     
Ruka MP, Plante C, Mallard BA, Foster RA, Cockshutt, Miller C, Abrams-Ogg ACG, Janzen EG, Butler DG.
Accuracy and fate of Ultrasound -guided injection of activated charcoal into the neck and peritoneal cavity of
the 56-day-old fetal pig
. Joint Annual Meeting of the Canadian Association of Transplantation and the Canadian
Transplantation Society, Montreal, Quebec, Canada, September 13-17, 1995. Scientific Abstract Book, p 42, abstract
no. 32. ( poster presentation)
59.    Foster WG,
Ruka MP, Foster RA, Janzen EG. Histopathological characteristics of endometrial implants in a new
mouse model of endometriosis
. (submitted)
60.    
Ruka MP, Plante C, Mallard BA, Abrams-Ogg ACG, Butler DG. Pig/dog chimerism (50/50) detected in the
peripheral blood lymphocytes (PBL) of pig-fetus at 105 days of gestation
. 67th Annual Meeting of The Royal
College of Physicians and Surgeons of Canada, Canadian Association of Pathologists, Toronto, Ontario, Canada,
September 24-27, 1998, (poster presentation), Clinical and Investigative Medicine 1998; (Supplement) S81: 393


                                                     APPENDIX II

                                                                                                                              Number of Operations
                                                                                                    Laboratory         Performed from 1974
Index        Experimental Operations *                                                    Animal **               to present
                                                                                                                                                                              
1          Long-term portal and hepatic veins cannulation                               dog                         126
2          Liver preservation and transplantation                                            dog/pig                        40
3          Liver denervation                                                                                    dog                              5
4          Liver bacteriology                                                                                   dog                              6
5          Hemoperfusion through an activated charcoal
  column                                                                                                         dog                            30
6          Experimental common bile duct obstruction                                    dog                            24
7          Implantation of the Gore Tex prosthesis into
  common bile duct                                                                                    dog                            24
8          Heart transplantation                                                                            dog                              6
9          Experimental interruption of the heart left
  bundle divisions                                                                                      dog                           41
10        Kidney Auto- and Allo- transplantation ***                                  dog                         253
11        Experimental renal hypertension                                                       dog                           18
12        Ileum transplantation                                                                           dog                           10
13        Experimental ileum obstruction                                                         dog                           45
14        Experimental ileum edema                                                                  dog                           20
15        Thoracic duct cannulation                                                                  dog                         252
16        Gore-Tex prosthesis implantation into thoracic
  duct and femoral vein                                                                               dog                           23
17        Ileum and liver lympathic vessels cannulation                                 dog                          34
18        Lymphatic vessels and lymph node perfusion
  -in vivo                                                                                                      dog                            57
19        Lymph node transplantation                                                              dog                             6
20        Leg afferent and efferent lymph vessels
  cannulation                                                                                                dog                         135
21        Experimental lymphoedema (Elephantiasis)                                     dog                          75
22        Lymphatic vessel to vein vessel implantation                                  dog                            7
23        Arteriovenous fistula (Aorta to V.Cava)                                          dog                             8
24        Liver and kidney rabbit-to-dog xenograft
  transplantation                                                                             rabbit/dog                       124
25        Skin transplantation                                                                            dog                           54
26        Thymectomy in puppies                                                                    dog                             5
27        Interstitial fluid pressure measurement
  (Guyton's sphere implantation into the lung
  and subcutaneously)                                                                                 dog                            30
28        Bone-like material implantation to the femoral bone                      dog                            21
29        Oesophageal muscular layers reconstruction by a
  carbon-fiber prostheses implantation                                                     rabbit                         75
30        Trachea reconstruction by implanted P.E.U.
   prostheses                                                                                                    rabbit                        19
31        Urinary bladder wall reconstruction using the
  PLL/PU membrane                                                                                       rabbit                          8
32        Artificial lenses implantation into cornea                                              rabbit                         6
33        Rat pancreas preservation (96 hrs) for transplantation                             rat                       314
34        Pancreas allo-transplantation (cuff technique)
  from white Wistar-donor to BB-rat recipient                                                 rat                          12
35        Total pancreatectomy in Yellow Baboon to induce
  diabetes and for islets of Langerhans isolation                                      monkey                       5
36        Canine liver allo-transplantation        dog        4
37        Canine pancreas preservation (96 hrs) for transplantation                    dog                         27
38        Canine kidney preservation (96 hrs) for transplantation                       dog                         37
39        Piglet kidney preservation (96 hrs) for transplantation                         piglet                        9
40        Pig-to-dog kidney xenograft transplantation                                   piglet/dog                      4
41        Pig-to-pig kidney autograft transplantation                                           piglet                        3
42        Guyton's sphere implantation into rat’s liver                                           rat                        12
43        Model of endometriosis in B6C3F1 mice                                              mouse                     51
44        Model of partially sialoadenectimized rats                                               rat                        54
45        Cannulation of Ductus Thoracicus in rats                                                 rat                          3
46        Surgical vs. MRI evaluation of polycystic kidneys
  in DBA/2 FG-pcy mice (female and male)                                              mouse                        5
47        Gnotobiotic Surgery (caesarian section; pathogen free)****       pigs/fetuses              10
______________________________________________________________________________

TOTAL                                                                                                                                   2,137
___________________________________________________________________

*     
This List does not include operations which were performed in clinical small animal-patients (dogs and cats) such as:
ovariectomy, ovariohysterectomy, testectomy, prostatectomy, mastectomy, penile amputation, enterectomy, gastric
torsion, bone fracture, patellar reposition, hip dysplasia, extirpation of anal glands etc. (Holland, Poland, Canada)

**    Dog - mongrel dog, Beagle; pig - white domestic pig, Duroc - wild Iraqi pig and MHC defined miniature pig (Guelph,
Ontario, - colony);
monkey - Yellow Baboon, Rhesus Macaques; rabbit -white New Zealand; rat - White Wistar, BB
-rat - spontaneously diabetic;
mouse - strain B6C3F1 and DBA/2 FG-pcy

***       (a) Kidney auto-transplantation after warm (60, 90, and 120 min. in abdominal cavity) or cold (24 hrs. in 4°C) storage.
       (b) Kidney allo-transplantation with various protocols of immunosuppression to abrogate or in some specific protocols
        to enhance graft rejection.

****    Surgery carried out on transgenic pigs created by using embryo-transfer technology established at the University of
     Guelph (in 1997-1999, Ontario Veterinary College) for the purpose of delivering piglets expressing human genes
     following protocol(s) established by Dr. White of Immutran Inc. (Cambridge, England). This program was brought
     into existence, supervised and fully financially sponsored by NOVARTIS Pharmaceutical Corporation.




                                                      APPENDIX III

POSTGRADUATE COURSES AND MEETINGS ATTENDED:

1.  Microvascular Surgery Training, Central Animal Laboratory, Medical Faculty, Groningen, Holland, April-May 1984.
2.  
Experimental Eye Surgery, Dr. Jan Worst Research Group, Groningen, Holland, March-July 1985.
3.  Training Course in Safe Handling of Radioactive Materials organized by Dr. Azuwuike Owunwanne, Department of
Nuclear Medicine at the Faculty of Medicine, Kuwait University Health Science Centre, Kuwait, October 11-15, 1986.
4.  An International Symposium on Bio-ethics and Applied Ethnology, Montreal, Canada, August 15-16, 1987.
5.  
Introduction to Computers and VAX-VMS, course organized by Drs. H. Razouki and S. Malki at the Computer Unit,
Faculty of Medicine, Kuwait University, Kuwait, April 16-20, 1988.
6.  
An Educational Course on Tissue and Organ Transplantation, Sydney, Australia, August 13-14, 1988.
7.  Second Kuwait International Symposium on Ophthalmology, Kuwait, February 3-7, 1989.
8.
 Innovations in vascular surgery: Laser vascular surgery and vascular prosthesis. Seminar organized by Dr. R. Guidoin,
University Laval, Quebec City, Canada, November 17, 1989.
9.  
Electron microscopic picture of tissue reactivity when biomaterial grafts are implanted into soft and hard tissues. Seminar
organized by Dr. R. Guidoin, Institut de génie des matériaux -CNCR Boucherville, Montreal, Canada, September 29, 1989.
10.
 "Oxygen stress" workshop organized by Dr. E.G. Janzen at the Department of Clinical Studies, OVC, University of
Guelph, Guelph, Ontario, Canada, December, 1990.
11.  
"MRI in animal research for agriculture, veterinary medicine and biological models." Workshop organized by Dr. E.G.
Janzen at the Department of Clinical Studies, OVC, University of Guelph, Guelph, Ontario, Canada, June 17, 1991.
12.  American Society of
Transplant Physicians, 10th Annual Meeting at Fairmont Hotel, Chicago, Illinois, USA, May 28
-29, 1991.
13.  American Society of
Transplant Surgeons, 17th Annual Meeting at Fairmont Hotel, Chicago, Illinois, USA, May 29
-31, 1991.
14.  First International Congress on Xenotransplantation, Minneapolis, Minnesota, USA, August 25-28, 1991.
15.  International (second) Symposium on Small Bowel Transplantation, University Hospital in London, Ontario, Canada,
October 3-5, 1991.
16.  American Society of
Transplant Physicians, 11th Annual Meeting, Chicago Hilton and Towers, Chicago, IL, USA,
May 26-27, 1992.
17.  American Society of
Transplant Surgeons 18th Annual Meeting, Chicago Hilton and Towers, Chicago, IL, USA,
May 27-29, 1992.
18.  Molecular biology in organ transplantation. ASTP/ASTS Upjohn Symposium, Chicago Hilton and Towers, Chicago,
IL, USA, May 26, 1992.
19.  
Immunosuppression and highlights in transplantation. The third ASTS postgraduate course, Chicago Hilton and
Towers, Chicago, IL, USA, May 29-30, 1992.
20.  
MRI - User - Seminar; Organized by Dr. E.G. Janzen, University of Guelph, Arboretum, 3rd December, 1992.
21.  First ASTP Satellite Basic Science Symposium
Transplantation Immunobiology, Sheraton Chicago Hotel and Towers,
Chicago, IL, USA, May 15, 1994.
22.  American Society of Transplant Physicians, 13th Annual Meeting, Sheraton Chicago Hotel and Towers, Chicago, IL,
USA, May 16-18, 1994.
23.  ASTP/ASTS Joint Symposium, High-risk transplantation (cytomegalovirus infection). Sheraton Chicago Hotel and
Towers, Chicago, IL, USA, May 18, 1994.
24.  American Society of Transplant Surgeons, 20th Annual Meeting, Sheraton Chicago Hotel and Towers, Chicago, IL,
USA, May 18-20, 1994.
25.  Fifth ASTS Postgraduate Course, Sheraton Chicago Hotel and Towers, Chicago, IL, USA, May 20-21, 1994.
26.  
"Coping with Animal Mortality in Research and Teaching". Workshop organized by Human Resources at the Central
Animal Facility (lectures delivered by Dr. Denna Benn and Dr. Cindy Adams), University of Guelph, Guelph,
Ontario, Canada, April 5, 1995.
27.  
"Preventing Animal Related Diseases in People". Workshop organized by Human Resources (lectures delivered by
Dr. John Prescott), at the Central Animal Facility, University of Guelph, Guelph, Ontario, Canada, April 25, 1995.
28.  The 4th International Congress for Xenotransplantation, Nantes, France, September 7-11, 1997.
29.  TRANSPLANTATION 1999 –
Comprehensive Update and Review, The Westin Harbor Castle, Toronto, Ontario,
Canada, July 30-August 1, 1999.
30.  
Focus Group Meeting to Maintain the Quality of Veterinary Practice organized by Harry Cummings & Associates
Inc. Consulting Group, at the Guelph Youth Music Centre located at 75 Cardigan Street in Guelph, Ontario,
Canada, Monday January 17, 2005.
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